| 王齐敏,于香莉,吕 丽.靶向治疗药物的分子靶点蛋白在三阴性乳腺癌中的表达及临床意义[J].肿瘤学杂志,2014,20(9):710-714. |
| 靶向治疗药物的分子靶点蛋白在三阴性乳腺癌中的表达及临床意义 |
| Expressions of the Target Proteins for Target Therapy in Triple Negative Breast Cancer and Their Clinical Significance |
| 投稿时间：2014-06-02 |
| DOI：10.11735/j.issn.1671-170X.2014.09.B004 |
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| 中文关键词: 三阴性乳腺癌 分子靶点蛋白 免疫组织化学 |
| 英文关键词:triple negative breast cancer(TNBC) target protein immunohistochemistry |
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| 中文摘要: |
| 摘 要：［目的］ 检测靶向药物的靶点蛋白在三阴性乳腺癌中的表达。［方法］ 采用免疫组织化学方法检测VEGF、p53、MMP-9、MMP-2、PKC-α、Bcl-2、CD117、BRCA1、COX-2蛋白在34例三阴性乳腺癌中的表达。［结果］ 9种蛋白均有不同程度的表达，VEGF、p53和MMP-9阳性表达率97.1%、70.6%和73.5%，且表达量均较高。VEGF蛋白与MMP-9蛋白表达呈正相关（r=0.387，P=0.024），p53蛋白与MMP-2蛋白表达呈正相关（r=0.536，P=0.001）。基底细胞样乳腺癌Bcl-2蛋白表达量和阳性率均高于非基底细胞样乳腺癌 (P＜0.05）。［结论］ VEGF、p53和MMP-9蛋白可能是三阴性乳腺癌靶向治疗的潜在靶点，且在三阴性乳腺癌的发生发展过程中具有协同作用。 |
| 英文摘要: |
| Abstract: ［Purpose］ To investigate the expressions of target proteins for targeted therapy in triple negative breast cancer(TNBC). ［Methods］ The expressions of VEGF，p53，MMP-9，MMP-2，PKC-α，Bcl-2，CD117，BRCA1 and COX-2 in 34 cases with TNBC were detected immunohistochemically.［Results］ There were varying degree expressions of the 9 proteins in TNBC. The positive expression rates of VEGF，p53 and MMP-9 were 97.1%，70.6% and 73.5% respectively，all with high expression levels. There was positive correlation in protein expression between VEGF and MMP-9(r= 0.387，P=0.024)，or between p53 and MMP-2(r=0.536，P=0.001). Bcl-2 protein expression rate and expression level were significantly higher in basal-like breast cancer than those in non-basal-like breast cancer(P<0.05).［Conclusion］ VEGF，p53 and MMP-9 might be potential targets for target therapy of TNBC，and they might have synergistic effect on carcinogenesis of TNBC. |
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