| 吴志明,邱海江,方孙阳.Annexin A3 在乳腺癌中的表达及意义[J].肿瘤学杂志,2014,20(9):705-709. |
| Annexin A3 在乳腺癌中的表达及意义 |
| The Expression of Annexin A3 in Breast Cancer and Its Significance |
| 投稿时间：2014-03-03 |
| DOI：10.11735/j.issn.1671-170X.2014.09.B003 |
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| 中文关键词: Annexin A3 乳腺肿瘤 淋巴结转移 |
| 英文关键词:Annexin A3 breast neoplasms lymph metastasis |
| 基金项目:浙江省医药卫生科技计划项目(2011KYB130) |
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| 摘要点击次数: 2021 |
| 全文下载次数: 1041 |
| 中文摘要: |
| 摘 要：［目的］ 探讨 Annexin A3 在乳腺癌中的表达及意义。［方法］ 通过免疫组化MaxvisionTM法和Western blot法检测50例乳腺正常组织、50例乳腺良性肿瘤、60例乳腺癌组织及50例转移淋巴结中的Annexin A3表达水平，并分析其与乳腺癌患者年龄、肿瘤大小及不同分期的关系。［结果］ 免疫组化结果显示Annexin A3在乳腺正常组织、乳腺良性肿瘤、乳腺癌、乳腺癌转移淋巴结中的阳性表达率分别为4.0%、12.0%、65.0%、88.0%，Annexin A3在正常乳腺组织中的表达与其在乳腺良性肿瘤中的表达差异无统计学意义(χ2=2.174，P=0.14 )；Annexin A3在乳腺良性肿瘤中的表达与其在乳腺癌组织中的表达差异具有统计学意义(χ2=31.691，P＝0.000 )；Annexin A3在乳腺癌组织中的表达与其在转移淋巴结组织中的表达差异具有统计学意义(χ2＝7.790，P＝0.005 )。乳腺瘤患者Annexin A3的表达在不同年龄、不同肿瘤大小和不同肿瘤分期中差异均无统计学意义(P>0.05 )。［结论］ Annexin A3在乳腺癌及转移淋巴结中高表达，在促进乳腺癌的发生、发展及转移中可能有一定的作用。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression and significance of Annexin A3 in breast cancer.［Method］ The expression level of the Annexin A3 in 60 cases with breast cancer tissues，50 metastatic lymph nodes，50 samples with breast benign tumor，and 50 samples of normal breast tissues were detected by immunohistochemical method MaxvisionTM and Western blot method. And the relationship of Annexin A3 expression with age，tumor size，and staging of breast cancer patient was analyzed. ［Results］ The positive rate of Annexin A3 in normal breast tissue，breast benign tumor，breast cancer and metastatic lymph node was 4.0%，12.0%，65.0% and 88.0% respectively. The expression of Annexin A3 in normal breast tissue had no significant difference with that in breast benign tumor(χ2=2.174，P=2.174).The expression of Annexin A3 in breast benign tumor was significantly different with that in breast cancer tissue (χ2= 31.691，P=0.000).The expression of Annexin A3 in breast cancer tissue is significantly different with that in metastatic lymph node(χ2=7.790，P=0.005). There was no significant difference of expression of Annexin A3 in breast cancer patients between different ages，different tumor sizes and different tumor stages(P>0.05).［Conclusion］ High expression of Annexin A3 in breast cancer tissue and metastatic lymph node might play certain role in carcinogenesis and metastasis of breast cancer. |
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