| 闫 鲲,孟宏涛.CD47在肾细胞癌预后评价中的应用价值[J].肿瘤学杂志,2014,20(8):668-672. |
| CD47在肾细胞癌预后评价中的应用价值 |
| The Value of CD47 on the Prognostic Evaluation of Renal Cell Carcinoma |
| 投稿时间：2014-02-17 |
| DOI：10.11735/j.issn.1671-170X.2014.08.B012 |
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| 中文关键词: 肾肿瘤 CD47 预后 |
| 英文关键词:renal neoplasms CD47 prognosis |
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| 中文摘要: |
| 摘 要：［目的］ 研究CD47 分子在肾细胞癌（RCC）组织中的表达情况、临床意义及其在预后评价中的应用价值。［方法］ 收集37例RCC 患者的组织标本，同时以25例肾移植供肾的标本作为对照。实时定量PCR法和Western blot法分别检测各样本组织中CD47 mRNA和蛋白的表达量。生存分析探讨CD47 表达与患者预后情况的关系。Cox 比例风险模型分析影响患者生存时间的危险因素。［结果］ RCC 组织中CD47 的mRNA 和蛋白表达量明显高于正常肾脏组织。CD47 高表达组的中位生存时间和3 年生存率明显低于低表达组。多因素分析表明，CD47 表达水平、肿瘤直径、肿瘤分化程度及肿瘤TNM 分期是影响RCC 患者生存时间的独立危险因素。［结论］ CD47 在RCC 组织中表达增高，且高表达CD47 患者预后较差。CD47 在RCC 患者的预后判断中具有较好的应用价值。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of CD47 in renal cell carcinoma (RCC) tissues and to evaluate its relationship with RCC pathological features and prognosis. ［Methods］ A total of 37 RCC patients and 25 healthy donors in renal transplantation from our hospital were enrolled. Expression of CD47 mRNA and protein was tested by quantitative Real-time PCR and Western blot respectively. The prognosis of the patients was analyzed by survival analysis. Cox proportional hazard model was used for the relationship between prognosis and related features. ［Result］ The mRNA and protein expressions of CD47 were significantly higher in RCC tissues than those in healthy donor tissues. The median survival time and 3-year survival rate in high expression group were lower than those in the low expression group. The result of multivariate analysis showed that CD47 expression，tumor size，tumor differentiation and tumor TNM stage were all the independent predictors for the survival of RCC. ［Conclusions］ The expression of CD47 in RCC tissue is high and high expression group has a worse prognosis. Expression of CD47 relates to the clinical pathological feature of tumor and can be used as an independent predictor for RCC. |
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