黄 山,黄盛鑫,王 琪.趋化因子CXCL5及受体CXCR2在肝细胞癌中的表达及其与临床预后的关系[J].肿瘤学杂志,2014,20(8):659-663. |
趋化因子CXCL5及受体CXCR2在肝细胞癌中的表达及其与临床预后的关系 |
Expression of CXCL5 and CXCR2 in Hepatocellular Carcinoma and Its Relationship with Prognosis |
投稿时间:2014-06-10 |
DOI:10.11735/j.issn.1671-170X.2014.08.B010 |
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中文关键词: 肝肿瘤 趋化因子 CXCL5 CXCR2 预后 |
英文关键词:hepatocellular neoplasms chemokine CXCL5 CXCR2 prognosis |
基金项目:广西自然科学基金资助项目(2012jjAA40482) |
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中文摘要: |
摘 要:[目的] 探讨趋化因子CXCL5及其受体CXCR2与肝细胞癌(HCC)的临床病理特征和术后复发的关系。[方法] 根据随访结果,分为早期复发组、非早期复发组和无复发组。运用荧光定量PCR检测3组肝癌患者组织中CXCL5和CXCR2的相对表达量。[结果] CXCL5在早期复发组的相对表达量高于无复发组(P=0.011);与临床分期和HBsAg状态有关(P<0.05)。CXCR2在早期复发组的相对表达量高于无复发组(P<0.001),同时高于非早期复发组(P=0.005);与临床分期、肿瘤直径和HBsAg状态有关(P<0.05)。CXCL5-CXCR2共同高表达患者的5年累积生存率明显低于其他患者(P=0.005)。[结论] CXCL5和CXCR2在肝癌中高表达,并与临床病理特征和术后复发有关。CXCL5和CXCR2有望成为肝癌术后预后判断的指标。 |
英文摘要: |
Abstract:[Purpose] To investigate the expression of chemokine CXCL5 and its receptor CXCR2 in hepatocellular carcinoma(HCC) and its relationship with clinical pathological features and prognosis.[Methods] Based on the results of follow-up,all patients were divided into early relapse group,non-early relapse group and relapse-free group. The relative expression of CXCL5 and CXCR2 in the three groups of HCC patients was detected by quantitative PCR.[Results] The relative expression of CXCL5 in early relapse group was higher than that in relapse-free group(P=0.011),and it related to clinical stages and status of HBsAg(P<0.05). The relative expression of CXCR2 in early relapse group was higher than that in relapse-free group(P<0.001) and non-early relapse group(P=0.005),and it related to clinical stages,diameter of tumor and status of HBsAg(P<0.05). 5-year cumulative survival rate in patients with co-expression of CXCL5-CXCR2 was significantly lower than that in other patients(P=0.005). [Conclusion] The expression of CXCL5 and CXCR2 in HCC relates to clinico-pathological characteristics and postoperative relapse. Therefore,CXCL5 and CXCR2 can be expected to become a potential index for postoperative prognosis of HCC. |
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