| 黄 山,黄盛鑫,王 琪.趋化因子CXCL5及受体CXCR2在肝细胞癌中的表达及其与临床预后的关系[J].肿瘤学杂志,2014,20(8):659-663. |
| 趋化因子CXCL5及受体CXCR2在肝细胞癌中的表达及其与临床预后的关系 |
| Expression of CXCL5 and CXCR2 in Hepatocellular Carcinoma and Its Relationship with Prognosis |
| 投稿时间：2014-06-10 |
| DOI：10.11735/j.issn.1671-170X.2014.08.B010 |
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| 中文关键词: 肝肿瘤 趋化因子 CXCL5 CXCR2 预后 |
| 英文关键词:hepatocellular neoplasms chemokine CXCL5 CXCR2 prognosis |
| 基金项目:广西自然科学基金资助项目（2012jjAA40482） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨趋化因子CXCL5及其受体CXCR2与肝细胞癌(HCC)的临床病理特征和术后复发的关系。［方法］ 根据随访结果，分为早期复发组、非早期复发组和无复发组。运用荧光定量PCR检测3组肝癌患者组织中CXCL5和CXCR2的相对表达量。［结果］ CXCL5在早期复发组的相对表达量高于无复发组(P=0.011)；与临床分期和HBsAg状态有关（P<0.05）。CXCR2在早期复发组的相对表达量高于无复发组(P<0.001)，同时高于非早期复发组(P=0.005)；与临床分期、肿瘤直径和HBsAg状态有关（P<0.05）。CXCL5-CXCR2共同高表达患者的5年累积生存率明显低于其他患者(P=0.005)。［结论］ CXCL5和CXCR2在肝癌中高表达，并与临床病理特征和术后复发有关。CXCL5和CXCR2有望成为肝癌术后预后判断的指标。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of chemokine CXCL5 and its receptor CXCR2 in hepatocellular carcinoma(HCC) and its relationship with clinical pathological features and prognosis.［Methods］ Based on the results of follow-up，all patients were divided into early relapse group，non-early relapse group and relapse-free group. The relative expression of CXCL5 and CXCR2 in the three groups of HCC patients was detected by quantitative PCR.［Results］ The relative expression of CXCL5 in early relapse group was higher than that in relapse-free group(P=0.011)，and it related to clinical stages and status of HBsAg(P<0.05). The relative expression of CXCR2 in early relapse group was higher than that in relapse-free group(P<0.001) and non-early relapse group(P=0.005)，and it related to clinical stages，diameter of tumor and status of HBsAg(P<0.05). 5-year cumulative survival rate in patients with co-expression of CXCL5-CXCR2 was significantly lower than that in other patients(P=0.005). ［Conclusion］ The expression of CXCL5 and CXCR2 in HCC relates to clinico-pathological characteristics and postoperative relapse. Therefore，CXCL5 and CXCR2 can be expected to become a potential index for postoperative prognosis of HCC. |
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