| 周明镇,李东升,陈志坚.鼻咽癌常规放射治疗后10年以上生存者的随访观察[J].肿瘤学杂志,2014,20(7):551-554. |
| 鼻咽癌常规放射治疗后10年以上生存者的随访观察 |
| Over 10 Years Follow-up for Survivors with Nasopharyngeal Carcinoma After Conventional Radiotherapy |
| 投稿时间：2014-01-09 |
| DOI：10.11735/j.issn.1671-170X.2014.07.B005 |
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| 中文关键词: 鼻咽肿瘤 放射疗法 并发症 复发 肿瘤转移 |
| 英文关键词:nasopharyngeal neoplasms radiotherapy complication recurrence neoplasm metastasis |
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| 摘要点击次数: 1965 |
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| 中文摘要: |
| 摘 要：［目的］ 研究经常规放射治疗后生存10年以上的鼻咽癌患者的生存状况。［方法］ 对接受放射治疗后，生存超过10年且有完整随访复查资料的342例鼻咽癌患者，进行肿瘤控制情况和放疗晚期并发症调查。所有病人均接受过常规放疗，鼻咽中位剂量70Gy，颈部转移性淋巴结中位剂量66Gy，淋巴结阴性者颈部剂量50Gy。有54例病人给予同期化疗。中位随访期14年（10~23年）。［结果］ 342例中，在首程放疗的10年后，有27例局部区域复发，4例发生远处转移。10年后死亡24例，其中因鼻咽癌复发或转移死亡11例，为第1位死因；吞咽障碍导致死亡5例，为第2位死因。264例病人（79.7%）有1种或1种以上不同程度的晚期并发症。其中有1种或1种以上的3、4级严重并发症者98 例，占所有病人的28.6 %。［结论］ 鼻咽癌常规放疗后长期生存者大多存在不同程度的晚期并发症，部分存在影响正常生活的3、4级严重晚期并发症。放疗后生存10年以上者，仍可能发生局部区域肿瘤复发或者远处转移。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the outcomes of follow-up for the nasopharyngeal carcinoma(NPC) patients who survived over 10 years after conventional radiotherapy. ［Methods］ Cancer control and late complications in 342 followed-up NPC cases being alive over 10 years after radiotherapy were investigated. These cases were treated with conventional radiotherapy，with a median dose of 70Gy for nasopharyngeal lesion，66Gy for the neck in the cases with neck lymph node metastasis，50Gy prophylactic dose for the neck with negative node. Fifty-four cases received chemotherapy. The median follow-up was 14 years (rang 10~23 years). ［Results］There were 27 cases with local-regional cancer relapse，4 cases with distance metastasis. Twenty-four cases died 10 years after initial radiotherapy，among them 11 died of NPC recurrence or distant metastases，which accounted for the first cause of death；5 cases died of dysphagia，ranked the second cause of death.Two hundred and sixty-four casess（79.7%） occurred 1 or more late complications，and 98 of them(28.6 %) had 1 or more kind of late comlications with grade 3 or grade 4. ［Conclusion］ Various late complications exist in most long-term survivors with NPC after conventional radiotherapy. Partial of the survivors suffer from grade 3 or grade 4 complications which seriously affect the patients’ quality of life. Regional recurrence or distant metastasis might occur in long-term survivors. |
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