| 方燕红,陈韵彬,宗井凤.MRI诊断翼腭窝侵犯在鼻咽癌分期中意义[J].肿瘤学杂志,2014,20(7):538-541. |
| MRI诊断翼腭窝侵犯在鼻咽癌分期中意义 |
| Value of Pterygopalatine Fossa Involvement Diagnosed with MRI in Staging of Nasopharyngeal Carcinoma |
| 投稿时间：2014-03-17 |
| DOI：10.11735/j.issn.1671-170X.2014.07.B002 |
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| 中文关键词: 鼻咽肿瘤 翼腭窝 磁共振成像 分期 |
| 英文关键词:nasopharyngeal neoplasms pterygopalatine fossa magnetic resonance imaging |
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| 摘要点击次数: 2034 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨MRI发现的翼腭窝侵犯在鼻咽癌分期中的意义。［方法］ 回顾性分析基于MRI诊断的816例初诊鼻咽癌患者资料。T3（翼腭窝组）定义为T3期伴有翼腭窝侵犯而无T4期结构侵犯，比较T分期各亚组治疗后生存情况。Kaplan-Meier法计算生存率并用Log-rank法检验。鼻咽癌常规分割放疗与调强放疗鼻咽部复发率、远处转移率采用卡方检验。［结果］ 随访率为94.1%。鼻咽癌翼腭窝侵犯率为19.0%，均伴有T3或T3期以上结构侵犯。T分期中T2、T3、T3（翼腭窝组）的无局部复发生存、无远处转移生存曲线重合，但与T4期能拉开。鼻咽癌常规分割放疗与调强放疗鼻咽部复发率、远处转移率差异无统计学意义。［结论］ MRI诊断T3期合并翼腭窝侵犯的患者，若无合并其他T4期解剖结构受累，其无局部复发生存率、无远处转移生存率与T2、T3期相似，预后较T4期好。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the value of pterygopalatine fossa involvement diagnosed with MRI in staging of nasopharyngeal carcinoma(NPC).［Methods］ Data of 816 cases with NPC initially diagnosed with MRI were analyzed. Stage T3(pterygopalatine fossa group) was defined as patients with pterygopalatine fossa involvement，but without other T4 related anatomical structure extension. The survival of various subgroups of T stage were compared. The Kaplan-Meier method was used in the calculation of survival，and the statistical differences among survival curves was analyzed using the Log-rank test. Nasopharynx relapse rate and distant metastasis rate of conventional radiotherapy and intensity-modulated radiotherapy(IMRT) were analyzed by Chi-square test.［Results］ The follow-up rate was 94.1%. Pterygopalatine fossa involvement was seen in 19.0% patients，associated with the involvement of structures in stage T3. Local relapse-free survival（LRFS） and distant metastasis-free survival（DMFS） of the three groups of stage T2，T3 and T3 (pterygopalatine fossa group) were coincided and were well separated with stage T4. There were no significant difference of nasopharynx replase rate and distant metastasis rate between conventional radiotherapy and IMRT.［Conclusion］ For stage T3 patients with pterygopalatine fossa involvement on MRI but without other T4 related anatomical structure extension，they have the similar LRFS and DMFS to stage T2 and T3，and their prognosis are better than those of stage T4. |
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