| 郎妙双,马成美.高危型HPV负荷量与宫颈病变及术后随访的相关研究[J].肿瘤学杂志,2014,20(6):488-491. |
| 高危型HPV负荷量与宫颈病变及术后随访的相关研究 |
| The Correlation of High-risk Type Human Papillomavirus Load with Cervical Lesions and Follow-up After LEEP |
| 投稿时间：2013-11-16 |
| DOI：10.11735/j.issn.1671-170X.2014.06.B011 |
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| 中文关键词: 宫颈病变 人乳头瘤病毒 病毒负荷量 随访 |
| 英文关键词:cervical lesions human papillomavirus viral load follow up |
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| 中文摘要: |
| 摘 要：［目的］ 探讨高危型HPV负荷量与宫颈病变及术后病毒持续感染的关系。［方法］ 对2008年1月至2012年11月体检发现的高危型HPV阳性且行宫颈LEEP术的749例患者临床资料及随访结果进行分析，观察高危型HPV负荷量与宫颈病变及术后病毒持续感染的关系。［结果］ 高危型HPV负荷量越大，宫颈病变级别越高。术后3个月高危型HPV阳性率约27.9%；术后6个月约8.3%；术后9个月约4.0%。宫颈LEEP术后3、6个月患者高危型HPV阳性表达率下降显著（术后3个月vs术前：χ2=844.38，P=0.0001；术后6个月vs术后3个月：χ2=97.35，P=0.0001）；术后9个月高危型HPV阳性表达率较术后6个月下降，但无显著性差异。术前高危型HPV负荷量<100RLU/CO、100～1000RLU/CO及>1000RLU/CO三组术后6个月复查HPV阳性率分别为5.3%、9.4%及12.9%（P<0.05）。［结论］ 高危型HPV负荷量与宫颈病变严重程度及持续感染存在明显相关性，针对高负荷量者需严密诊治及随访。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the association between high-risk type human papillomavirus (HR-HPV) load and cervical lesions and postoperative regression of HR-HPV infection after LEEP.［Methods］ A total of 749 cases with positive HR-HPV and following LEEP were retrospectively analyzed. ［Results］ The greater the load of HR-HPV，the higher the grade of cervical lesion. About 27.9% of the patients were HR-HPV positive at 3 months after LEEP，and the rates were 8.3% and 4.0% at the 6 months and 9 months after LEEP respectively. The HR-HPV positive rate at 3 months after LEEP significantly decreased compared to that of the preoperation as well as decreased，to the rate at 6 months and 3 months(P<0.01). The HR-HPV positive rate at 9 months after LEEP decreased compared to that at 6 months，with no significant difference. The HR-HPV positive rate of the patients whose HR-HPV load was <100RLU/CO，100～1000RLU/CO and >1000RLU/CO were 5.3%，9.4% and 12.9% respectively（P<0.05）.［Conclusion］ There is a marked correlation of viral load of HR-HPV with cervical lesions and postoperative regression. It is important to treat and to follow up closely to the patients with high viral load of HR-HPV. |
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