| 徐春华,于力克,张 宇.肺癌脑转移患者的临床特征及预后分析[J].肿瘤学杂志,2014,20(6):468-470. |
| 肺癌脑转移患者的临床特征及预后分析 |
| Clinical Features and Prognosis for Lung Cancer Patients with Brain Metastasis |
| 投稿时间：2013-08-24 |
| DOI：10.11735/j.issn.1671-170X.2014.06.B007 |
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| 中文关键词: 肺肿瘤 脑转移 预后因素 |
| 英文关键词:lung neoplasms brain metastasis prognostic factor |
| 基金项目: |
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| 摘要点击次数: 1752 |
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| 中文摘要: |
| 摘 要：［目的］ 研究肺癌脑转移患者的临床特征及其相关的预后因素。［方法］ 对1997～2007年间诊治的158例肺癌脑转移患者的临床资料进行回顾性分析，采用Kaplan-Meier法进行单因素分析，Cox回归模型进行多因素分析。［结果］ 肺癌脑转移患者1、2、3年生存率分别为48.7％、21.5％和3.8％，中位生存期11.2个月。单因素分析显示行为状态评分、脑转移灶数目、有无颅外转移、治疗方法和血清CEA水平对生存期有影响。多因素分析显示，治疗方法、行为状态评分和有无颅外转移3个因素影响预后。［结论］ 治疗方法、行为状态评分和有无颅外转移可作为肺癌脑转移的独立预后因素。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate clinical features and independent predictors of survival in patients with brain metastasis from lung cancer.［Methods］ From 1997 to 2007，158 patients with brain metastasis from lung cancer were analyzed retrospectively. Univariate and multivariate analysis were performed by Kaplan-Meier methods and Cox regression models respectively. ［Results］ One-，2-，3- year survival rates were 48.7%，21.5% and 3.8% respectively. The median survival was 11.2 months in patients with brain metastasis from lung cancer. The univariate analysis showed that the survival correlated to performance status (PS)，number of brain metastasis，extracranial metastasis，therapeutic modality and serum CEA levels. Multivariate analysis showed that therapy modality，the PS score and extracranial metastases were independent influence factors for prognosis. ［Conclusion］ The therapeutic modality，PS score and extracranial metastasis may be considered as important index for predicting prognosis of brain metastasis from lung cancer. |
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