| 吴永凯,刘永煜.肿瘤抑制因子TIMP2在肺癌组织中的表达及其临床意义[J].肿瘤学杂志,2014,20(6):452-455. |
| 肿瘤抑制因子TIMP2在肺癌组织中的表达及其临床意义 |
| Expression of TIMP2 in Lung Cancer Tissues and Its Significance |
| 投稿时间：2014-04-15 |
| DOI：10.11735/j.issn.1671-170X.2014.06.B003 |
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| 中文关键词: TIMP2 肺肿瘤 肿瘤抑制因子 |
| 英文关键词:TIMP2 lung neoplasms tumor suppress gene |
| 基金项目: |
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| 中文摘要: |
| 摘 要：［目的］探讨肿瘤抑制因子TIMP2在肺癌组织中的表达及其与各临床指标关系。［方法］采用免疫组织化学染色方法检测94例肺癌患者肿瘤组织和相应的正常肺组织中TIMP2蛋白的表达水平。［结果］TIMP2蛋白的免疫组化染色显示主要为细胞浆着色。TIMP2肺泡阳性表达率为64.20%，支气管阳性表达率63.51%，肿瘤组织阳性表达率为30.85%。经统计学分析结果显示TIMP2蛋白肿瘤组织内表达水平与周围正常肺泡和支气管表达有明显差异（P<0.001）。［结论］肺癌组织中TIMP2蛋白水平显著降低，提示其在肺癌的发生过程中蛋白表达受到显著抑制。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of TIMP2 in lung cancer tissues and its relationship with clinical characteristics. ［Methods］ The TIMP2 protein levels in ninety-four tumor tissues and corresponding normal tissues，including squamous cell carcinoma(SCC) 42 cases， lung adenocarcinoma(ADC) 43 cases，small cell lung cancer(SCLC) 7 cases and others 2 cases，were examined by immunohistochemical(IHC). ［Results］ IHC results showed that positively stained of TIMP2 was 30.85% in tumor tissues，which was significantly lower than that in normal alveoli tissues (64.20%，P<0.001) and normal bronchial（63.51%，P<0.001）. ［Conclusion］ The expression level of TIMP2 protein decreases in lung cancer tissues，which indicates that its expression may be significantly suppressed in lung cancer carcinogenesis. |
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