| 曹玉娟,王德林,刘承伟.肺腺癌新分类在预测Ⅰb期非小细胞肺癌预后中的价值[J].肿瘤学杂志,2014,20(6):448-451. |
| 肺腺癌新分类在预测Ⅰb期非小细胞肺癌预后中的价值 |
| The Predictive Value of New Lung Adenocarcinoma Classification on the Prognosis of Non-small Cell Lung Cancer Stage Ⅰb |
| 投稿时间：2014-04-11 |
| DOI：10.11735/j.issn.1671-170X.2014.06.B002 |
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| 中文关键词: 癌，非小细胞肺 腺癌新分类 预后 |
| 英文关键词:NSCLC IASLC/ATS/ERS classification prognosis |
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| 中文摘要: |
| 摘 要：［目的］ 探讨新的肺腺癌分类在判断早期可手术的Ⅰb期非小细胞肺腺癌患者中的预后价值。［方法］ 回顾性分析168例非小细胞肺癌患者，根据第7版TNM分期明确诊断为Ⅰb期非小细胞肺腺癌。采用Kaplan-Meier法比较不同病理亚型患者的无复发生存期和总生存期。Cox回归分析探讨影响患者无复发生存期和总生存期的影响因素。［结果］ 168例患者中，无原位腺癌患者，2例患者为微浸润腺癌，51例患者为乳头状为主型，55例患者为腺泡样为主型，24例为微乳头为主型，20例为鳞屑状为主型，12例为实性为主型腺癌，4例为变异性腺癌（其中2例为实性腺癌，2例为胎儿型腺癌）。单因素分析显示，是否淋巴管/血管侵犯(P=0.042)和不同病理类型（P=0.004）是影响患者5年无复发生存的因素。多因素分析显示，病理类型是同时影响患者5年无复发生存和总生存期的惟一因素（P分别为0.002和0.035）。［结论］ 新肺腺癌分类在预测可手术的Ⅰb期非小细胞肺腺癌的无复发生存和总生存方面有一定的价值。 |
| 英文摘要: |
| Abstract： ［Purpose］ To investigate the relationship between new Lung Adenocarcinoma Classification and prognosis of lung adenocarcinoma stage Ⅰb.［Methods］ One hundred and sixty-eight patients with stageⅠ lung adenocarcinoma operated in Peking University Shougang Hospital，were identified between 2000 and 2010. Survival curves were plotted using the Kaplan-Meier method. The Cox proportional hazard model was used for multivariate analysis. ［Results］ None of the cases were adenocarcinoma in situ and two were minimally invasive adenocarcinomas. One hundred and sixty-six cases were invasive adenocarcinoma. Of those，51，55，24，12，20 and 4 were papillary predominant，acinar predominant，micropapillary predominant，solid predominant，lepidic predominant subtypes，and variants of invasive adenocarcinoma，respectively. Patients with micropapillary and solid predominant tumors had a significantly worse disease-free survival as compared to those with other subtypes predominant tumors (P<0.001). Multivariate analysis revealed that the new classification was an independent predictor of the disease-free and overall survival (P=0.002 and 0.035).［Conclusion］ The predominant subtype in the primary tumor is associated with prognosis of resected lung adenocarcinoma stage Ⅰ. |
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