杜宝昌,刘 军,王帅兵.早期应用双膦酸盐在晚期恶性肿瘤治疗中的作用[J].肿瘤学杂志,2014,20(5):406-408.
早期应用双膦酸盐在晚期恶性肿瘤治疗中的作用
The Role of Early Application of Bisphosphonates in the Treatment for Advanced Cancer
投稿时间:2013-09-27  
DOI:10.11735/j.issn.1671-170X.2014.05.B012
中文关键词:  肿瘤  双膦酸盐  骨转移  骨密度
英文关键词:neoplasms  bisphosphonate  bone metastases  bone mineral density
基金项目:廊坊市科学技术研究与发展计划项目(2012013080)
作者单位
杜宝昌 中国石油天然气集团公司中心医院河北医科大学石油临床学院 
刘 军 中国石油天然气集团公司中心医院河北医科大学石油临床学院 
王帅兵 中国石油天然气集团公司中心医院河北医科大学石油临床学院 
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中文摘要:
      摘 要:[目的] 探讨早期静脉应用双膦酸盐在晚期恶性肿瘤治疗中的作用。[方法] 128例晚期恶性肿瘤患者分为两组:早期应用双膦酸盐(确诊骨转移之前应用)患者64例为治疗组;未早期应用者64例为对照组。比较双膦酸盐治疗前后VAS 疼痛评分和Karnofsky 评分以及两组骨转移发生率及确诊时间。[结果] 双膦酸盐治疗前后VAS 疼痛评分为8.10±1.13,3.10±1.27 (t=24.96,P<0.01);Karnofsky 评分为57.00±7.80,69.00±8.60(t=8.77,P<0.05)。治疗组骨转移发生率26.56%(17/64),对照组59.37%(38/64),差异有统计学意义(χ2=14.06,P<0.01);治疗组中位骨转移发生时间较对照组延迟3个月(7个月 vs 4个月),差异有统计学意义(P=0.038)。[结论] 早期应用双膦酸盐治疗晚期恶性肿瘤,能够明显改善生活质量、减轻疼痛;可以减少骨转移发生率,并推迟骨转移发生时间。
英文摘要:
      Abstract:[Purpose] To investigate the role of early intravenous bisphosphonate in the treatment for advanced cancer.[Methods] One hundred and twenty-eight cases with advanced cancer were divided into two groups:64 patients as treatment group,with application of bisphosphonate before the diagnosis of bone metastases,which was defined as early use;64 patients as control group,without early use of bisphosphonate. VAS pain score,Karnofsky score and bone mineral density were compared before and after bisphosphonate treatment;bone metastasis incidence and time to diagnosis were compared in the two groups.[Results] VAS pain score before and after bisphosphonate treatment was 8.10±1.13 and 3.10±1.27 respectively(t=24.96,P<0.01);Karnofsky score,57.00±7.80 and 69.00±8.60 respectively(t=8.77,P<0.05). The incidence of bone metastasis was 26.56%(17/64) in treatment group,and 59.37%(38/64) in the control group(χ2=14.06,P<0.01);the median time to diagnosis of bone metastases was delayed for 3 months compared that to control group(7m vs 4m),with significant difference(P=0.038). [Conclusion] Early application of bisphosphonate in the treatment for advanced cancer may significantly improve the quality of life,reduce pain,reduce the incidence of bone metastases and postpone the occurrence of bone metastasis .
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