| 喻卫红,孙 涛,刘文中.374例恶性肿瘤患者化疗药物敏感性研究[J].肿瘤学杂志,2014,20(5):393-397. |
| 374例恶性肿瘤患者化疗药物敏感性研究 |
| Study on Sensitivity of Chemotherapeutic Agents in 374 Cases with Malignancy |
| 投稿时间：2013-11-04 |
| DOI：10.11735/j.issn.1671-170X.2014.05.B009 |
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| 中文关键词: 药物敏感性 化疗药物 个体化治疗 肿瘤细胞 |
| 英文关键词:drug sensitivity chemotherapy agent individualized treatment tumor cells |
| 基金项目:辽宁省科技厅科研事业发展专项（辽财指预201001） |
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| 中文摘要: |
| 摘 要：［目的］ 研究临床常用的抗肿瘤化疗药物对不同恶性肿瘤的抑制率，为临床个体化治疗提供参考。［方法］ 采用MTT法测定了化疗药物对374例恶性肿瘤患者原代肿瘤细胞的抑制率，比较不同药物在不同肿瘤中抑制率的差异，分析药物抑制率与年龄、性别的关系，观察药物对肿瘤细胞的抑制而产生的形态变化。［结果］ 不同药物对同一肿瘤的抑制率不同，差异有统计学意义（P＜0.05）。其中，肺癌对紫杉醇、洛铂、吉西他滨较敏感；乳腺癌对卡培他滨、顺铂、表阿霉素、奥沙利铂较敏感；头颈部癌对5氟尿嘧啶、博来霉素、异环磷酰胺较敏感；神经胶质瘤对卡莫司汀、顺铂、替尼泊苷较敏感；卵巢癌对奥沙利铂、阿霉素、表阿霉素较敏感。对男性肺癌的平均抑制率（30.71%）高于女性患者（29.38%），差异有统计学意义（t＝2.188，P＝0.029）。在乳腺癌、卵巢癌患者中，年龄与抑制率呈负相关。同类或不同药物作用下，瘤细胞均发生形态学改变，对瘤细胞产生程度不同的抑制作用，表现为明显的个体差异性。［结论］ 不同个体对抗肿瘤药物的敏感性具有明显差异，药物敏感性试验对临床选择化疗药物具有参考价值。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate inhibition rate of the clinical commonly used antineoplastic chemotherapeutic agents on various malignant tumor，to provide reference for individualized treatment. ［Methods］ Inhibition rate of chemotherapeutic agents on primary tumor cells of 374 cases with malignant tumor were determined by MTT method. The association of inhibition rate with age and gender was analyzed，and morphological changes of tumor cells inhibited by chemotherapeutic agents were observed. ［Results］ The inhibition of different drugs on the same tumor cells were different，with statistically significant difference(P<0.05). Lung cancer cells were sensitive to paclitaxel，lobaplatin and gemcitabine；Breast cancer cells were sensitive to capecitabine，cisplatin，epirubicin and oxaliplatin；Head and neck cancer cells were sensitive to fluorouracil，bleomycin and ifosfamide；Glioma cells were sensitive to carmustine，cisplatin and teniposide；Ovarian cancer cells were sensitive to oxaliplatin，adriamycin，epirubicin. The average inhibition rate of male patients with lung cancer(30.71%) was higher than that of female lung cancer patients(29.38%)，with significant difference(P=0.029). In breast cancer or ovarian cancer patients，negative correlation was found between age and inhibition. Under the action of the same kind or different drugs，inhibition of tumor cells were different，characterized by obvious individual differences.［Conclusion］ Different individual susceptibilities to chemotherapeutic agents are different，drug sensitive test provides reference value for clinical application of chemotherapy agents. |
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