| 邵吉宝,唐晓燕,姚根宏.非小细胞肺癌患者血清periostin水平及其临床意义[J].肿瘤学杂志,2014,20(5):373-375. |
| 非小细胞肺癌患者血清periostin水平及其临床意义 |
| The Level of Serum Periostin in Patients with Non-small Cell Lung Cancer and Its Clinical Significance |
| 投稿时间：2013-12-05 |
| DOI：10.11735/j.issn.1671-170X.2014.05.B005 |
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| 中文关键词: 肺肿瘤 periostin 酶联免疫吸附测定 |
| 英文关键词:lung neoplasms periostin enzyme-linked immunosorbent assay |
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| 中文摘要: |
| 摘 要：［目的］ 探讨非小细胞肺癌(NSCLC)患者血清periostin水平及其临床意义。［方法］ 采用酶联免疫吸附法(ELISA)检测102例 NSCLC患者和40例良性肺部疾病患者血清periostin水平，并以35例健康人血清作为对照，比较不同分期、有无转移及术后1年复发与否的患者之间是否存在差异。［结果］ NSCLC患者血清periostin水平［(38.6±18.7)ng/ml］显著高于健康对照者［(21.1±15.8)ng/ml，t=6.78，P<0.01］和良性肺部疾病者［(23.3±14.7)ng/ml，t=5.17，P<0.01］。Ⅲ/Ⅳ期患者血清periostin水平［(45.8±26.9)ng/ml］显著高于Ⅰ/Ⅱ期患者［(34.6±18.7)ng/mL，t=4.79，P<0.01］。有转移患者和术后1年内复发患者血清periostin水平分别高于无转移患者和无复发患者，差异均有统计学意义（t值分别为3.67，6.71，P<0.01）。［结论］ NSCLC患者血清periostin水平有可能作为肿瘤转移和术后复发的预测指标。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate serum periostin level in patients with non-small cell lung cancer(NSCLC) and its clinical significance. ［Methods］ Patients with NSCLC(n=102)，with benign lung disease(n=40) and healthy controls(n=35) were enrolled. Serum periostin level was measured by enzyme-linked immunosorbent assay(ELISA).The results were compared between patients with different tumor stages， with or without metastasis， with or without postoperative recurrence one year after surgery. ［Results］Patients with NSCLC had higher periostin levels［(38.6±18.7)ng/ml］ than patients with benign lung disease［(23.3±14.7)ng/ml，t=5.17，P<0.01］ and the control group［(21.1±15.8)ng/ml，t=6.78，P<0.01］.Serum periostin levels in stageⅢ/Ⅳpatients［(45.8±26.9)ng/ml］were significantly higher than those in stageⅠ/Ⅱpatients［(34.6±18.7)ng/ml， t=4.79，P<0.01］.Serum periostin levels were higher in patients with distant metastasis or postoperative recurrence than those without(t=3.67 and 6.71，both with P<0.01).［Conclusion］ Serum periostin level in patients with NSCLC might be a useful marker for predicting of metastasis and postoperative recurrence. |
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