| 王 晗,吴异兰,解方为.TRAIL对人肺腺癌细胞株Calu-3增殖和凋亡的影响[J].肿瘤学杂志,2014,20(5):369-372. |
| TRAIL对人肺腺癌细胞株Calu-3增殖和凋亡的影响 |
| Effect of TRAIL on the Proliferation and Apoptosis of Human Lung Adenocarcinoma Cell Line Calu-3 |
| 投稿时间：2014-01-12 |
| DOI：10.11735/j.issn.1671-170X.2014.05.B004 |
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| 中文关键词: 肺肿瘤 肿瘤坏死因子相关凋亡诱导配体 细胞增殖 细胞凋亡 |
| 英文关键词:lung neoplasms TRAIL cell proliferation cell apoptosis |
| 基金项目:国家自然科学基金（81274002）；福建省自然科学基金（2012J01383）；福建省自然科学基金面上项目（2010J01222） |
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| 中文摘要: |
| 摘 要：［目的］ 研究肿瘤坏死因子相关凋亡诱导配体（tumor necrosis factor-related apoptosis-inducing ligand，TRAIL）对人肺腺癌细胞株Calu-3增殖和凋亡的影响。［方法］ 用不同浓度TRAIL分不同时间段干预Calu-3细胞，MTT法检测细胞增殖抑制率，流式细胞仪检测细胞凋亡率。［结果］ Calu-3细胞生长被TRAIL抑制，具有浓度和时间依赖性。TRAIL能诱导Calu-3细胞凋亡。［结论］ TRAIL在体外具有抑制Calu-3细胞增殖，促使Calu-3细胞凋亡的作用。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the effect of TNF-related apoptosis inducing ligand (TRAIL) on the proliferation and apoptosis of the human lung adenocarcinoma cell line Calu-3. ［Methods］ Calu cells were treated with different concentrations of TRAIL at different times. Inhibition of proliferation and apoptosis of Calu-3 cells were detected by MTT assay and flow cytometry. ［Results］ The proliferation of Calu-3 cells were inhibited by TRAIL in a dose-time dependent manner. Apoptosis of Calu-3 cells was induced by TRAIL. ［Conclusion］ TRAIL could inhibit Calu-3 cells proliferation and induce cell apoptosis in vitro. |
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