中文关键词: OCT4 肺肿瘤 肿瘤干细胞 信号通路 预后 |
英文关键词:lung neoplasms cancer stem cell signaling pathway prognosis |
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摘要点击次数: 1938 |
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中文摘要: |
摘 要:OCT4是POU转录因子家族的成员之一,在维持干细胞的多能性、自我更新及调节肿瘤干细胞的增殖、分化中起到至关重要的作用。文章拟对OCT4在肺癌肿瘤干细胞中的功能、信号通路及OCT4与肺癌临床指标及预后的相关性作一综述。 |
英文摘要: |
Abstract:OCT4,a member of POU transcription factor family,plays a critical role in maintaining the pluripotency and automatic renewal of stem cells,and regulates the proliferation and differentiation of cancer stem cells. The article concisely reviews the function of OCT4 in lung cancer stem cell(LCSC),its signaling pathway,and the correlations between OCT4 expression and clinicopathological factors and prognosis of patients with lung cancer. |
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