孙国贵,崔大为,程云杰.CCNG2在鼻咽癌中的表达及其临床意义[J].肿瘤学杂志,2014,20(4):316-319. |
CCNG2在鼻咽癌中的表达及其临床意义 |
Expression of CCNG2 in Nasopharyngeal Cancer and Its Significance |
投稿时间:2013-09-10 |
DOI:10.11735/j.issn.1671-170X.2014.04.B011 |
|
|
中文关键词: CCNG2 鼻咽肿瘤 预后 肿瘤转移 |
英文关键词:CCNG2 nasopharyngeal neoplasms prognosis tumor metastasis |
基金项目: |
|
摘要点击次数: 2103 |
全文下载次数: 935 |
中文摘要: |
摘 要:[目的] 探讨细胞周期蛋白G2(CCNG2) 在鼻咽癌中的表达及其意义。[方法] 采用免疫组织化学方法、Western Blot检测87例鼻咽癌组织和34例正常鼻咽组织中CCNG2蛋白的表达情况。[结果] 免疫组织化学结果表明,CCNG2蛋白在鼻咽癌组织及正常鼻咽组织中的表达阳性率分别为37.9%、91.2%,差异有统计学意义(P<0.05)。Western Blot结果表明,CCNG2 的蛋白在鼻咽癌组织的相对表达量较正常鼻咽组织明显降低,差异亦具有统计学意义(P<0.05)。CCNG2蛋白表达与鼻咽癌T分期、临床分期及分化程度有关(P<0.05)。[结论] 鼻咽癌组织中CCNG2蛋白表达明显减低,且与鼻咽癌T分期、临床分期及肿瘤分化有关。 |
英文摘要: |
Abstract:[Purpose] To investigate the expression of Cyclin G2(CCNG2) in nasopharyngeal carcinoma and its clinical significance.[Methods] Immunohistochemistry and Western Blot assays were used to analyze CCNG2 protein expression in 87 samples of nasopharyngeal cancer tissue and 34 samples of normal nasopharyngeal tissue.[Results] The positive rate of CCNG2 protein expression was significantly lower in nasopharyngeal cancer tissues than that in normal tissues(P<0.05). The relative amount of CCNG2 protein in nasopharyngeal cancer tissues was significantly lower than that in normal tissues (P<0.05). The expression of CCNG2 protein correlated to T stage,clinic stage and histological grade (P<0.05). [Conclusion] CCNG2 expression is low in nasopharyngeal cancer and correlates to T stage,clinic stage and histological grade. |
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |