| 张旭初,王荣福,张建华.18F-FDG PET/CT与血清CEA测定联合应用对结直肠癌术后复发与转移的临床诊断价值[J].肿瘤学杂志,2014,20(4):300-304. |
| 18F-FDG PET/CT与血清CEA测定联合应用对结直肠癌术后复发与转移的临床诊断价值 |
| The Clinical Value of the Combination of 18F-FDG PET/CT and Serum CEA on the Diagnosis for Recurrence and Metastasis of Colorectal Cancer Postoperation |
| 投稿时间：2014-03-07 |
| DOI：10.11735/j.issn.1671-170X.2014.04.B008 |
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| 中文关键词: 结直肠肿瘤 复发 转移 正电子发射断层显像术/X线计算机 癌胚抗原 |
| 英文关键词:colorectal neoplasms recurrence metastasis positron emission tomography/X-ray computed tomography carcinoembryonic antigen |
| 基金项目:国家重大科学仪器设备开发专项（2011YQ03011409）； |
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| 中文摘要: |
| 摘 要：［目的］ 探讨18F-FDG PET/CT在结直肠癌术后血清CEA升高患者探测复发及转移灶中的应用。［方法］ 64例结直肠癌术后血清CEA升高患者均进行了18F-FDG PET/CT显像，并与病理及临床随访结果进行比较。［结果］ PET/CT诊断阳性56例，1例假阳性；阴性8例，2例假阴性。PET/CT诊断灵敏度为96.5%，特异性为85.7%，阳性预测值为98.2%，阴性预测值为75.0%，准确率为93.8%。［结论］ 应用18F-FDG PET/CT检查对于结直肠癌术后血清CEA升高患者复发及转移灶的探测具有较高的灵敏度及特异性，血清CEA升高可以作为18F-FDG PET/CT检查前初筛的良好指标。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the clinical value of 18F-FDG PET/CT for detecting the recurence and metastasis of the elevated serum carcinoembryonic antigen (CEA) in patients with colorectal cancer postoperation. ［Methods］ 18F-FDG PET/CT were performed in 64 patients with elevated CEA. PET/CT results were compared with the final histopathological and clinical follow-up findings.［Results］ PET/CT was positive in 56 patients and negative in 8 patients. After correlated with histopathology or radiology and clinical follow-up，PET/CT was false positive in 1 patient，false negative in 2 patients. The sensitivity，specificity，positive predictive value，negative predictive value and accuracy of 18F-FDG PET/CT were 96.5%，85.7%，98.2%，75.0% and 93.8%，respectively. ［Conclusion］ 18F-FDG PET/CT can significantly improve diagnostic accuracy in patients with colorectal cancer postoperation. The elevated serum CEA is an effective signal for the patients that should be detective by PET/CT for finding recurrence of colorectal cancer. |
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