| 中文关键词: 乳腺肿瘤 有机氯农药 气相色谱 六六六 滴滴涕 |
| 英文关键词:breast neoplasms organochlorine pesticides gas chromatography hexachlorocyclohexane(HCH) dichlorodiphenyltrichloroethane(DDT) |
| 基金项目:河北省科学技术研究指导计划项目(98276176) |
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| 中文摘要: |
| 摘 要：［目的］ 研究有机氯农药暴露与乳腺癌发生的关系。［方法］ 运用病例对照研究，收集177例乳腺疾病患者的血液（5ml）和脂肪组织（10g）标本，运用气相色谱仪检测病例组（乳腺癌患者）和对照组（乳腺良性疾病患者）血清和脂肪组织中的有机氯农药残留。［结果］ 患者的居住地在病例组和对照组之间有差异（χ2=4.70，P=0.03），将城市与农村患者分层。城市和农村患者，血清中β-HCH和PCTA暴露在病例组和对照组之间差异有统计学意义（P<0.001）；脂肪组织中β-HCH、PCTA和PP′-DDE暴露在病例组和对照组之间亦差异有统计学意义（P<0.001）。血清和脂肪组织中，有机氯农药暴露增加乳腺癌的患病风险，OR值均大于2。［结论］ 有机氯农药暴露可能与乳腺癌的发生有关。 |
| 英文摘要: |
| Abstract:［Purpose］ To explore the relationship between organochlorine pesticides exposure and the incidence of breast cancer. ［Methods］ A case-control study was conducted in 177 cases of breast diseases. Fasting blood sample (5ml) and breast adipose tissue specimens(10g) were collected from every subject. The organochlorine residue level in serum and fat were measured by gas chromatography. ［Results］ The residence was significant different between case group and control group(χ2=4.70，P=0.03).City and county patients were stratified. In city and county patients，serum β-HCH and PCTA level were significant different between case group and control group(P<0.001). Fat β-HCH，PCTA and PP′-DDE level were significant different between case group and control group (P<0.001). Exposure of organochlorine pesticides was a risk factor of breast cancer. In serum and fat，the ORs were all more than 2. ［Conclusions］ Organochlorine pesticides exposure might correlate to carcinogenesis of breast cancer. |
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