| 李秀翠,蒋 华,姜维美.D-dimer及PF1+2与晚期恶性肿瘤患者静脉血栓栓塞症的相关性的研究[J].肿瘤学杂志,2014,20(3):234-237. |
| D-dimer及PF1+2与晚期恶性肿瘤患者静脉血栓栓塞症的相关性的研究 |
| The Correlation of D-dimer and PF1+2 in Malignant Patients with Venous Thromboembolism |
| 投稿时间：2014-01-15 |
| DOI：10.11735/j.issn.1671-170X.2014.03.B014 |
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| 中文关键词: 肿瘤 静脉血栓栓塞症 D-dimer PF1+2 |
| 英文关键词:neoplasms venous thromboembolism D-dimer PF1+2 |
| 基金项目:连云港市卫生局科研项目（1017） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨血浆D-dimer及PF1+2与晚期恶性肿瘤患者静脉血栓栓塞症(VTE)的相关性。［方法］ 150例晚期恶性肿瘤患者随机分为2组，其中117例无VTE的患者为非栓塞组，33例发生VTE的患者为栓塞组。所有患者均在化疗前及第2、第4、第6个疗程化疗后第7d至第10d期间检测血浆中D-dimer和PF1+2的含量。［结果］随着化疗的进行患者血浆D-dimer、PF1+2呈上升趋势，且栓塞组高于非栓塞组(P<0.05)；恶性肿瘤患者血浆中D-dimer和PF1+2呈显著正相关关系(r=0.53，P<0.05)，而D-dimer、PF1+2与患者的年龄、性别、病程、病理分型、临床分期均无相关性(P>0.05)；多因素Logistic回归分析结果显示：血浆D-dimer、PF1+2是化疗后VTE发生的独立危险因素，而接受抗凝治疗是化疗后VTE发生的保护因素。［结论］血浆D-dimer、PF1+2对晚期恶性肿瘤患者VTE的发生具有一定的诊断价值，接受化疗的晚期恶性肿瘤患者应采取适当的抗凝治疗预防VTE的发生。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the correlation of D-dimer and PF1+2 with in malignant patients complicated with venous thromboembolism(VTE). ［Methods］ One hundred and fifty malignancies were randomly divided into two groups：non-embolization group(117 cases without VTE) and embolization group(33 cases with VTE). The plasma D-dimer and PF1+2 were tested in all patients before chemotherapy，and at the seventh day to the tenth day during the second，fourth，sixth course of chemotherapy respectively. ［Results］The plasma D-dimer，PF1+2 increased with the progress of chemotherapy，and the embolization group had higher leves than the the non-embolization group(P<0.05).The D-dimer and PF1+2 had a significant positive correlation in malignant patients(r=0.53，P<0.05)，while the D-dimer，PF1+2 had no correlation with the patient’s age，gender，duration of disease，pathological type，clinical stage (P>0.05).Logistic regression analysis showed that plasma D-dimer，PF1+2 were the independent risk factors for VTE after chemotherapy，and anticoagulation therapy after chemotherapy was the protective factor for VTE. ［Conclusion］ Plasma D-dimer，PF1+2 have diagnostic value for VTE in malignant patients. The advanced cancer patients undergoing chemotherapy treatment should take anticoagulation therapy to prevent the occurrence of VTE. |
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