| 陈文军,董崇海,田字彬.C-myc在结直肠癌和息肉中的表达及其意义[J].肿瘤学杂志,2014,20(3):226-229. |
| C-myc在结直肠癌和息肉中的表达及其意义 |
| Expression and Significance of C-myc in Colorectal Cancer and Colorectal Polyps |
| 投稿时间：2013-06-14 |
| DOI：10.11735/j.issn.1671-170X.2014.03.B012 |
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| 中文关键词: 结直肠息肉 结直肠肿瘤 c-myc 免疫组织化学 |
| 英文关键词:colorectal polyps colorectal neoplasms c-myc immunohistochemistry |
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| 中文摘要: |
| 摘 要：［目的］ 探讨c-myc在结直肠癌发生、发展中的作用及其与临床病理特征的相关性。［方法］ 采用免疫组织化学SP法检测60例结直肠癌组织、60例结直肠息肉组织、30例结直肠癌旁组织中c-myc 蛋白表达。［结果］ 结直肠癌、结直肠腺瘤性息肉组织中c-myc蛋白表达阳性率明显高于结直肠增生性息肉及癌旁黏膜组织。c-myc蛋白高表达与结肠癌发病部位、肿瘤分化程度、Dukes分期、淋巴结转移有关（P均<0.05）。c-myc蛋白高表达与结直肠腺瘤性息肉大小以及息肉有蒂或无蒂相关（P<0.05）。［结论］ c-myc表达与结直肠癌发生、发展有关。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the role of c-myc in carcinogenesis and development of colorectal cancer，and the correlation between its expression and clinicaopathological features in colorectal cancer. ［Methods］ The expressions of c-myc protein in colorectal cancer(n=60)，colorectal polyps(n=60)，and cancer adjacent tissues(n=30) were detected by SP immunohistochemical assay. ［Results］ The expression rates of c-myc in colorectal cancer and colorectal adenomatous polyps were significantly higher than those in colorectal hyperplastic polyps and cancer adjacent tissues. Overexpression of c-myc had a significant correlation with the tumor location，differentiation，Dukes’ stage and lymph node metastasis(P<0.05). High expression of c-myc correlatied to the tumor size and with or without tumor pedicle(P<0.05)．［Conlusion］ Expression of c-myc correlates to the carcinogenesis and development of colorectal cancer. |
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