| 童海光,谢聪颖,林权冰.预后评分系统GPA在肺癌脑转移患者中的应用[J].肿瘤学杂志,2014,20(3):221-225. |
| 预后评分系统GPA在肺癌脑转移患者中的应用 |
| Application of Prognostic Index Graded Prognostic Assessment （GPA） in Lung Cancer with Brain Metastases |
| 投稿时间：2013-12-18 |
| DOI：10.11735/j.issn.1671-170X.2014.03.B011 |
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| 中文关键词: 肺肿瘤 脑转移 预后 分级预后评估（GPA） |
| 英文关键词:lung cancer brain metastasis prognosis graded prognostic assessment(GPA) |
| 基金项目: |
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| 中文摘要: |
| 摘 要：［目的］ 评价ＧＰＡ（graded prognostic assessment）分级在评价肺癌脑转移瘤患者预后中的作用。［方法］ 回顾性分析109例肺癌脑转移患者的临床资料，按GPA 系统进行ＧＰＡ评分，采用Kaplan-Meier进行生存分析并进行Log-rank检验。［结果］ 单因素分析显示患者的Karnofsky评分（KPS评分）、脑转移灶数目、颅外转移对肺癌脑转移患者生存期有影响（P<0.05）。ＧPA 0～1分组中位生存期为8 个月(95%CI：4.64~11.36)，1.5～2.5分组中位生存期12个月(95%CI：9.16~14.83)，3~4分组中位生存期25个月(95%CI：5.87~44.13)，不同GPA评分患者的中位生存期差异有统计学意义(χ2=7.467，P=0.024)。［结论］ GPA作为一个预后模型，是有用的肺癌脑转移预测模型。 |
| 英文摘要: |
| Abstract： ［Purpose］ To investigate the role of graded prognostic assessment(GPA） in the evaluation of prognosis for lung cancer patients with brain metastasis.［Methods］ The clinical data of 109 lung cancer patients with brain metastases were reviewed retrospectively. GPA were evaluated according to GPA system. Survival was analyzed with Kaplan-Meier method and Log-rank test was used.［Results］ The univariate analysis showed that Karnofsky score(KPS score)，number of brain metastases，extracranial metastasis had influence on survival of lung cancer patients with brain metastases (P<0.05). The median survival was 8 months(95%CI：4.64～11.36) in group with GPA 0~1，12 months (95%CI：9.16～14.83) in group with GPA 1.5~2.5，25 months (95%CI：5.87～44.13) in group with GPA 3~4. The median survival of patients with different GPA score were statistically significant(χ2= 7.467，P=0.024). ［Conclusion］ GPA is useful for prediction of brain metastases from lung cancer. |
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