| 王欣彦,王 敏,高 嵩.多西他赛联合奥沙利铂治疗部分敏感复发性上皮性卵巢癌疗效评价[J].肿瘤学杂志,2014,20(3):213-215. |
| 多西他赛联合奥沙利铂治疗部分敏感复发性上皮性卵巢癌疗效评价 |
| Efficacy of Docetaxel Combined with Oxaliplatin in the Treatment for Partly Platinum-sensitive Recurrent Epithelial Ovarian Cancer |
| 投稿时间：2013-12-20 |
| DOI：10.11735/j.issn.1671-170X.2014.03.B009 |
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| 中文关键词: 卵巢肿瘤 药物敏感性 肿瘤复发 多西他赛 奥沙利铂 药物疗法 |
| 英文关键词:ovarian neoplasms drug sensitivity neoplasm recurrence docetaxel oxaliplatin drug therapy |
| 基金项目: |
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| 摘要点击次数: 1980 |
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| 中文摘要: |
| 摘 要：［目的］评价多西他赛联合奥沙利铂治疗部分敏感复发上皮性卵巢癌的临床疗效及安全性。［方法］回顾性分析应用多西他赛联合铂类方案治疗的43例部分敏感复发上皮性卵巢癌患者的临床资料。［结果］多西他赛+奥沙利铂组（治疗组）总有效率为58.3%，1年生存率为87.5%，无进展生存时间为（7.2±2.6）个月，均略高于多西他赛+卡铂组（对照组），但无统计学意义（P>0.05）。治疗组不良反应主要为血液系统毒性，其次为消化道反应和周围神经感觉异常。治疗组血液学毒性明显低于对照组，P=0.000；两组均无Ⅲ级至Ⅳ级胃肠道反应及周围神经感觉异常。［结论］多西他赛联合奥沙利铂方案治疗部分铂类敏感复发上皮性卵巢癌疗效较好，不良反应轻，可作为部分敏感复发上皮性卵巢癌的化疗方案。 |
| 英文摘要: |
| Abstract：［Purpose］ To evaluate the efficacy and safety of docetaxel combined with oxaliplatin in the treatment for partly platinum-sensitive recurrent epithelial ovarian cancer.［Methods］ Clinical data of 43 patients with partly platinum-sensitive recurrent epithelial ovarian cancer treated with docetaxel combined with oxaliplatin or docetaxel combined with carboplatin were analyzed retrospectively.［Results］ The response rate of docetaxel combined with oxaliplatin group(treatment group) was 58.3%；1-year survival rate，87.5%；progression free survival，(7.2±2.6) months，without significant difference compared with docetaxel combined with carboplatin group(control group) (P>0.05). The most common toxicities were myelosuppression，gastrointestinal symptoms and peripheral nerve paresthesia in treatment group. The myelosuppression in treatment group was alleviated as compared with control group，with significant difference(P=0.000). There were no grade 3 or 4 gastrointestinal symptoms and peripheral nerve paresthesia in both groups. ［Conclusions］ Docetaxel combined with oxaliplatin shows encouraging response and manageable toxicity for patients with partly platinum-sensitive recurrent epithelial ovarian cancer，which might offer a viable option for the patients with partly platinum-sensitive recurrent epithelial ovarian cancer. |
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