| 林世龙,杨国良,张连华.瘦素在非肌层浸润性膀胱癌中的表达及其意义[J].肿瘤学杂志,2014,20(2):131-134. |
| 瘦素在非肌层浸润性膀胱癌中的表达及其意义 |
| Expression of Leptin in Non-muscle-invasive Bladder Cancer and Its Significance |
| 投稿时间：2013-08-19 |
| DOI：10.11735/j.issn.1671-170X.2014.02.B011 |
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| 中文关键词: 膀胱肿瘤 瘦素 预后 |
| 英文关键词:bladder neoplasms leptin prognosis |
| 基金项目:上海市科学技术委员会面上项目（12ZR1417700） |
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| 中文摘要: |
| 摘 要： ［目的］ 探讨瘦素在非肌层浸润性膀胱癌中的表达情况，组织并分析其与膀胱癌患者临床病理特征及预后的关系。［方法］ 收集112例膀胱移行细胞癌组织和20例正常膀胱组织的病理切片，采用免疫组化方法检测膀胱癌和正常膀胱组织中瘦素的表达。［结果］ 正常膀胱组织中瘦素的表达水平明显低于肿瘤组织（P=0.032）。在低级别、高级别膀胱癌中，瘦素的阳性表达率分别为43.8%、75.8%，差别有统计学意义（P=0.001）。本组随访6~102个月，其中67例出现复发。复发组与未复发组中瘦素的阳性表达率分别为70.1%和46.7%，差别有统计学意义（P=0.013）。但瘦素表达与患者年龄、性别、肿瘤数目、大小及分期无明显相关性（P>0.05）。［结论］ 瘦素表达在膀胱癌组织中明显高于正常膀胱组织，瘦素的检测有助于膀胱癌诊断及预后评估。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of leptin in non-muscle-invasive bladder cancer and its relationship with clinical features and prognosis.［Methods］ The expression of leptin in 112 specimens of non-muscle-invasive bladder cancer and 20 specimens of normal bladder tissues was detected by immunohistochemtry.［Results］ The positive rate of leptin was significantly higher in bladder cancer tissues than that in normal bladder tissues（P=0.032）. The positive rate of leptin was 43.8% in low grade bladder cancer，75.8% in high grade，with significant difference(P=0.001). The patients were followed up for 6~102 months，and 67 patients were recurrent. The expression of leptin was significantly higher in recurrence group than that in non-recurrence group(70.1% vs 46.7%，P=0.013). The positive rate of leptin related to tumor grade and recurrence(P<0.05)，but not with sex，age，tumor number，size and stage(P>0.05). ［Conclusion］ The expression of leptin is higher in superficial bladder cancer. The detection of the expression of leptin is helpful to diagnosis and prognostic evaluation in non-muscle-invasive bladder cancer. |
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