| 龚 磊,黄志煜,杨海燕.晚期肺腺癌外周血CK19、CK20、MMP-9 mRNA的表达及其相关性[J].肿瘤学杂志,2013,19(12):964-969. |
| 晚期肺腺癌外周血CK19、CK20、MMP-9 mRNA的表达及其相关性 |
| Expressions of CK19，CK20，MMP-9 mRNA in Peripheral Blood in Patients with Advanced Lung Adenocarcinoma |
| 投稿时间：2013-10-14 |
| DOI：10.11735/j.issn.1671-170X.2013.12.B012 |
|
 |
| 中文关键词: 肺肿瘤 腺癌 外周血 细胞角蛋白 基质金属蛋白酶 |
| 英文关键词:lung neoplasms adenocarcinoma peripheral blood cytokeratin matrix metalloproteinase |
| 基金项目: |
|
| 摘要点击次数: 1826 |
| 全文下载次数: 927 |
| 中文摘要: |
| 摘 要：［目的］探讨晚期肺腺癌患者外周血中MMP-9、CK19、CK20 mRNA的表达水平及相关关系。［方法］ 应用RT-PCR结合Real Time PCR方法测定85例Ⅳ期肺腺癌患者外周血中CK19、CK20、MMP-9 mRNA拷贝数。以良性疾病患者34例、健康志愿者22名作为对照。［结果］ 晚期肺腺癌组患者外周血中CK19、CK20、MMP-9 mRNA中位值均显著高于健康对照及肺良性疾病人群，差异具有统计学意义（P<0.05）。随着CK19 mRNA的检测值增高，CK20 mRNA检测值也呈现增高趋势（r=0.885，P=0.000）。而MMP-9 mRNA表达与CK19 mRNA或CK20 mRNA无关。［结论］晚期肺腺癌外周血中CK19、CK20和MMP-9 mRNA显著高表达。CK19 mRNA和CK20 mRNA的表达呈正相关，且均与MMP-9 mRNA表达无关。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate expressions of MMP-9，CK19 and CK20 mRNA in peripheral blood in patients with advanced lung adenocarcinoma and their correlation. ［Methods］ MMP-9，CK19 and CK20 mRNA were detected in peripheral blood of 85 cases with lung adnocarcinoma stage Ⅳ by RT-PCR combined with Real Time PCR，with 34 cases with benign lung disease and 22 healthy volunteers as controls. ［Results］ The median level of MMP-9，CK19 and CK20 mRNA in patients with advanced lung adenocarcinoma were higher than those in benign lung disease patients and healthy controls. CK20 mRNA increased with the increasing of CK19 mRNA(r=0.885，P=0.000).However，no correlation was found in MMP-9 mRNA with CK19 mRNA or CK20 mRNA.［Conclusion］ MMP-9，CK19 and CK20 mRNA are overexpressed in patients with advanced lung adenocarcinoma. Expressions of CK19 mRNA and CK20 mRNA are positively correlated，and but have no correlation with MMP-9 mRNA expression. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |