| 林白桦,贾勇士,詹文明.肌肽对C57小鼠放射性肺损伤保护作用的机理研究[J].肿瘤学杂志,2013,19(12):954-958. |
| 肌肽对C57小鼠放射性肺损伤保护作用的机理研究 |
| The Protected Effect of Carnocine on Radiation-induced Lung Injury in C57 Mice |
| 投稿时间：2013-09-29 |
| DOI：10.11735/j.issn.1671-170X.2013.12.B010 |
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| 中文关键词: 肌肽 肺损伤 保护作用 转化生长因子-β1 |
| 英文关键词:carnosine lung injury prevention TGF-β1 |
| 基金项目:浙江省医药卫生科技计划项目(2010KYA017、2013KYB027) |
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| 中文摘要: |
| 摘 要：［目的］ 观察肌肽（carnosine）对C57BL 小鼠放射性肺损伤（RILI）的防护效果，并探讨其机制。［方法］ 将120只C57BL雌性小鼠随机分为对照组、给药组、辐照组和辐照+给药组，治疗后检测血清转化生长因子β1（TGF-β1）、丙二醛（MDA），以及部分肺组织羟脯氨酸（HYP）水平。［结果］除辐照后第7d血清中MDA水平各处理组间无明显差异（P>0.05），其余不同组间各时间段TGF-β1、MDA以及肺组织HYP水平差别均具有统计学意义（P＜0.05或<0.01）。给药组较对照组未出现明显副作用。［结论］ 肌肽能降低血清、肺组织中TGF-β1、MDA、HYP含量，并具有减轻放射性肺损伤的作用，且几乎无副作用，在防治放射性肺损伤中显示出良好前景。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the intervention of carnosine on radiation-induced lung injury in C57 mice.［Methods］ A total of 120 mice C57/BL(female) were divided into 4 groups：control group，carnosine group，irradiation group and irradiation plus carnosine group. After treatment，serum transforming growth factor-?茁1(TGF-?茁1)，malondialdehyde(MDA) were detected by ELISA assay and thiobarbituric acid colorimetric method respectively，while hydroxyproline(HYP) in parts of lung tissues was detected by spectrophotography.［Results］ After irradiation for 7d，MDA levels of serum had no significant difference in the 4 groups(P>0.05). However，TGF-?茁1 levels of serum，MDA levels of serum and HYP levels of lung tissue had significant difference at different time periods (P<0.05 or P<0.01).［Conclusions］ Carnosine is able to reduce the level of TGF-?茁1，MDA，HYP and improve radiation-induced lung injury in mice. Carnosine is less toxicity and shows a good prospect in the treatment for radiation-induced lung injury. |
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