| 唐明灯,刘道佳,林端瑜.乳腺癌18F-FDG PET/CT显像SUVmax与Ki67、ER、PR、Her-2的关系[J].肿瘤学杂志,2013,19(12):944-946. |
| 乳腺癌18F-FDG PET/CT显像SUVmax与Ki67、ER、PR、Her-2的关系 |
| The Correlation Between FDG Uptake and Expressions of Ki67，ER，PR，Her-2 in Breast Cancer |
| 投稿时间：2013-11-13 |
| DOI：10.11735/j.issn.1671-170X.2013.12.B008 |
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| 中文关键词: 乳腺肿瘤 体层摄影术，发射型计算机 体层摄影术，X线计算机 脱氧葡萄糖 |
| 英文关键词:breast neoplasms tomography,emission-computed tomography,X-ray competed deoxyglucose |
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| 摘要点击次数: 1822 |
| 全文下载次数: 950 |
| 中文摘要: |
| 摘 要：［目的］探讨18F-FDG PET/CT显像SUVmax与免疫组化指标Ki67、ER、PR、Her-2的关系。［方法］选择2011年10月至2012年12月经手术或活检证实为乳腺癌患者46例，在手术或活检前一周内行PET/CT检查，并将肿瘤组织行Ki67、ER、PR、Her-2检测。数据统计采用Pearson直线相关分析和独立分组t检验。［结果］SUVmax为1.2~13.0，平均为6.630±3.250；Ki67为10%~80%，平均值为43.040%±23.200%，SUVmax与Ki67呈正相关（r=0.752，P=0.000）；ER阳性组SUVmax为5.700±2.195，阴性组SUVmax为7.673±4.438，差异有统计学意义（t=-1.370，P=0.003）；PR阳性组SUVmax为6.285±2.761，PR阴性组SUVmax为7.110±4.434，差异无统计学意义（t=-0.549，P=0.099）；Her-2阳性组SUVmax为6.706±3.480，Her-2阴性组SUVmax为6.420±4.064，差异无统计学意义（t=0.157，P=0.912）。［结论］ SUVmax可反映乳腺癌组织中Ki67的表达水平，并有助于确认ER的表达状态，SUVmax高的乳腺癌ER表达状态可能为阴性，但SUVmax与乳腺癌PR、Her-2的表达状态无关。 |
| 英文摘要: |
| Abstract：［Purpose］ To evaluate the correlation between SUVmax over tumor foci on 18F-FDG PET/CT scan and biomarkers of Ki67，ER，PR and Her-2.［Methods］ Forty-six breast carcinoma patients underwent 18F-FDG PET/CT scan. The tumor specimens were analyzed by immunohistochemical staining for Ki67，ER，PR and Her-2. Pearson linear correlation and independent t-test were applied for statistical analysis．［Results］ The mean 18F-FDG SUVmax and Ki67 index were 6.630±3.250（range：1.2~13.0） and 43.040%±23.200%（range：10%~80%）respectively. SUVmax positively correlated with Ki67（r=0.752，P=0.000）.The mean 18F-FDG SUVmax of ER(+) group and ER(-) group were 5.700±2.195 and 7.673±4.438 respectively，with significant difference(P<0.05). The mean 18F-FDG SUVmax of PR(+) group and PR(-) group were 6.285±2.761 and 7.110±4.434 respectively，without significant difference(P>0.05).The mean 18F-FDG SUVmax of Her-2(+) group and Her-2(-) group were 6.706±3.480 and 6.420±4.064 respectively，without significant difference(P>0.05).［Conclusion］ 18F-FDG SUVmax may reflect the expression level of Ki67 and may be helpful to confirm expression status of ER where a tumor with a higher 18F-FDG SUVmax usually indicates the tumor with no or less expression of ER. But 18F-FDG SUVmax does not correlate to expression of PR and Her-2 in breast cancer. |
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