| 王 琪,胡伟国,宋启斌.PTEN表达水平与转移性结直肠癌患者西妥昔单抗临床获益关系的Meta分析[J].肿瘤学杂志,2013,19(11):846-853. |
| PTEN表达水平与转移性结直肠癌患者西妥昔单抗临床获益关系的Meta分析 |
| Meta Analysis on Association of PTEN Expression with Clinical Benefit of Cetuximab Therapy for Metastatic Colorectal Cancer |
| 投稿时间：2013-09-09 |
| DOI：10.11735/j.issn.1671-170X.2013.11.B005 |
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| 中文关键词: 结直肠肿瘤 PTEN 西妥昔单抗 肿瘤转移 免疫组织化学 Meta分析 |
| 英文关键词:colorectal neoplasms PTEN cetuximab neoplasm metastasis immunohistochemistry Meta analysis |
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| 中文摘要: |
| 摘 要：［目的］ 评价PTEN表达水平与转移性结直肠癌（mCRC）患者西妥昔单抗临床获益之间的关系，为临床用药和个性化治疗提供参考。［方法］ 计算机检索PubMed、CNKI、CBM和万方中文数据库，采用Meta分析的方法，评价PETN表达与mCRC患者西妥昔单抗疗效的关系。［结果］共纳入文献14篇，病人总人数1 227人。未经K-ras基因筛选mCRC患者PTEN表达阳性与西妥昔单抗治疗敏感性及无进展生存（PFS）均相关。K-ras野生型mCRC患者PTEN表达阳性与西妥昔单抗治疗PFS、总生存（OS）获益有关。［结论］ PTEN表达水平可以作为mCRC患者西妥昔单抗临床获益的预测因素。 |
| 英文摘要: |
| Abstract：［Purpose］ To evaluate the association between PTEN expression and the clinical benefit of cetuximab therapy for metastatic colorectal cancer (mCRC) patients. ［Methods］ Literatures were retrieved in PubMed，CNKI，CBM and Wanfang Data. A Metaanalysis was used to analyze the association between expression of PTEN and cetuximab effects in mCRC patients. ［Results］ A total of 14 retrospective studies and 1 227 cases were included in the Meta-analysis. The results showed that positive PTEN expression was correlated to sensitivity of cetuximab and progression-free survival (PFS) in mCRC patients unselected of K-ras gene. In patients with wild-type K-ras，positive PTEN predicted longer PFS and overall survival(OS). ［Conclusion］ PTEN expression is a predictive factor for clinical benefit in mCRC patients treated with cetuximab. |
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