| 陈华江,凌 昕,李 浦.局部晚期胃癌患者术后调强放疗的临床观察[J].肿瘤学杂志,2013,19(11):842-845. |
| 局部晚期胃癌患者术后调强放疗的临床观察 |
| Postoperative Intensity Modulated Radiotherapy for Locally Advanced Gastric Cancer |
| 投稿时间：2013-08-19 |
| DOI：10.11735/j.issn.1671-170X.2013.11.B004 |
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| 中文关键词: 胃肿瘤 放射疗法 放射治疗剂量 调强放疗 |
| 英文关键词:gastric neoplasms radiotherapy radiation dosage intensity modulated radiation therapy |
| 基金项目: |
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| 中文摘要: |
| 摘 要：［目的］ 比较局部晚期胃癌患者术后调强放疗(IMRT)与三维适形放疗(3D-CRT)计划，观察术后IMRT的不良反应及临床疗效。［方法］ 对46例局部晚期胃癌患者术后同时作IMRT及3D-CRT计划，处方剂量4500cGy，分割剂量180cGy。［结果］ 与3D-CRT相比，IMRT靶区剂量分布更好，平均剂量更高(P＜0.05)，肝脏平均受照剂量明显降低(P＜0.05)，左肾V12.5、V22.5亦显著降低(P＜0.05)。46例患者1年及2年生存率分别为98.0%、80.0%，死亡的6例患者中有5例发生了远处转移。［结论］ 对局部晚期胃癌患者，相对3D-CRT，术后IMRT靶区剂量分布更好，临床不良反应可耐受。 |
| 英文摘要: |
| Abstract：［Purpose］ To compare the radiotherapy plan between intensity modulated radiation therapy (IMRT) and 3-dimensional conformal radiation therapy (3D-CRT) and to determine the efficacy and toxicity of postoperative IMRT for locally advanced gastric cancer. ［Methods］ Forty-six patients with locally advanced gastric cancer were included in this study. For each patient IMRT and 3D-CRT radiotherapy plan were generated. The median radiation dose delivered was 4 500cGy，with 180cGy per fraction.［Results］ IMRT had better target dosimetric distribution and higher average dose compared with 3D-CRT(P＜0.05). IMRT plan significantly reduced the mean dose of liver(P＜0.05) and V12.5 and V22.5 of left kidney(P＜0.05). The 1-year and 2-year overall survival were 98.0% and 80.0% respectively. Of the six death patients，five developed distant metastasis. ［Conclusion］ Compared to 3D-CRT，IMRT has advantages in target dosimetric distribution，with tolerable toxicities. |
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