| 于丽丽,李琳琳,柳 红.As2O3联合Aspirin对615小鼠移植性前胃癌淋巴道转移的影响[J].肿瘤学杂志,2013,19(10):776-782. |
| As2O3联合Aspirin对615小鼠移植性前胃癌淋巴道转移的影响 |
| The Effect of As2O3 Combined with Aspirin on Infiltration and Lymphatic Metastasis of MFC in 615 Inbreeding Mice |
| 投稿时间：2013-08-14 |
| DOI：10.11735/j.issn.1671-170X.2013.10.B008 |
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| 中文关键词: As2O3 Aspirin 胃肿瘤 淋巴道转移 |
| 英文关键词:As2O3 Aspirin gastric neoplasms lymphatic metastasis |
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| 中文摘要: |
| 摘 要：［目的］ 观察As2O3和Aspirin联合应用对615小鼠前胃癌侵袭、淋巴管生成及淋巴道转移的影响。［方法］ 建立小鼠前胃癌淋巴道移植瘤模型，用As2O3、Aspirin单独及联合作用后，测量各组小鼠体重、瘤重，计算肿瘤抑制率并计数瘤组织微淋巴管密度（LMVD）。［结果］ 与NS组相比，各治疗组615小鼠移植瘤生长均受抑制，Aspirin组抑瘤率为15.4%，As2O3组抑瘤率为43.8%，减半联合组为45.6%，联合组为60.4%，差异有统计学意义（P<0.05）。淋巴结内瘤组织转移抑制率As2O3组为22.4%，减半联合组和联合组分别为28.6%和50.0%。联合治疗组与减半联合组、Aspirin组、As2O3组及NS组相比，LMVD计数均显著减少，差异有统计学意义（P<0.05）。［结论］ As2O3与Aspirin联合应用可抑制小鼠前胃癌移植瘤的生长、侵袭和淋巴道转移。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the effect of As2O3 in combination with Aspirin on the infiltration and lymphatic metastasis of highly metastasic mouse forestomach squamous carcinoma (MFC) in 615 inbreeding mice. ［Methods］ We set up 615 high-metastatic models of mouse tumor，giving different concentrations of As2O3 and Aspirin. The body weight，tumour weight were measured and the tumor inhibition rate was calculated，and the microlymphatic vessel density (LMVD) was counted.［Results］ The weight of tumors in 615-strain mice treated with As2O3 combined aspirin was significantly lower than that of the others groups(P<0.05). The inhibition rate of tumor weight was 15.4% in Aspirin group，43.8% in As2O3 group，45.6% in the half-dose combination group，60.4% in combination group. The tumor metastasis inhibition rate in lymph node，As2O3 group was 22.4%，half-dose combination group was 28.6%，and combination group was 50.0%. LMVD in tumor tissues treated with drugs were evidently lower than that in the saline group(P<0.05)，especially the combination group. ［Conclusion］ As2O3 in combination with Aspirin could inhibit the growth，invasion and lymphatic metastasis of tumor tissue in 615-strain mice. |
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