| 徐春华,于力克.胎盘多肽注射液在晚期非小细胞肺癌患者化疗中的作用[J].肿瘤学杂志,2013,19(10):772-775. |
| 胎盘多肽注射液在晚期非小细胞肺癌患者化疗中的作用 |
| Effect of Placenta Polypeptide Injection in Combination with Chemotherapy in the Treatment for Advanced Non-small Cell Lung Cancer |
| 投稿时间：2013-08-25 |
| DOI：10.11735/j.issn.1671-170X.2013.10.B007 |
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| 中文关键词: 胎盘多肽注射液 癌，非小细胞肺 吉西他滨 顺铂 |
| 英文关键词:pacenta polypeptide injection carcinoma,non-small cell lung gemcitabine cisplatin |
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| 中文摘要: |
| 摘 要：［目的］ 探讨胎盘多肽注射液在Ⅲ、Ⅳ期非小细胞肺癌(NSCLC)化疗中的作用。［方法］ 经病理学或细胞学检查确诊的Ⅲ、Ⅳ期NSCLC患者随机分为治疗组与对照组。治疗组48例，采用胎盘多肽注射液联合吉西他滨+顺铂方案化疗；对照组50例，单纯采用吉西他滨+顺铂方案化疗。每4周为1个周期，化疗4个周期。每2个周期评价疗效，监测治疗前后患者外周血白细胞(WBC)、血小板(PLT)、T细胞亚群及血清免疫球蛋白(Ig)含量变化。［结果］ 治疗组和对照组有效率分别为52.1％和48.0％(P>0.05)。治疗组胃肠道反应和骨髓抑制较对照组轻，差异有统计学意义(P<0.05)。化疗后治疗组CD8+和CD4+/CD8+较对照组高，差异有统计学意义(P<0.05)。治疗组化疗后KPS评分明显高于对照组(P<0.05)。化疗后治疗组血清IgM和IgG含量与对照组比较，差异有统计学意义(P<0.05)。［结论］ 胎盘多肽注射液联合吉西他滨+顺铂方案治疗Ⅲ、Ⅳ期NSCLC疗效较好，患者不良反应轻，且具有提高机体的免疫功能和改善患者生活质量的作用。 |
| 英文摘要: |
| Abstract：［Purpose］ To explore the enhancing effect of placenta polypeptide injection in the chemotherapy for patients with non-small cell lung cancer (NSCLC) stage Ⅲ and Ⅳ. ［Methods］ A total of 98 patients with advanced NSCLC were enrolled in this study. The patients were treated with either placenta polypeptide injection in combination with GP(GEM+DDP) chemotherapy(gemcitabine and cisplatin，n=48)，or with GP(GEM+DDP) chemotherapy alone(n=50). The chemotherapy was performed for 4 cycles，4 weeks as a cycle and the response was evaluated every 2 weeks. The following indicators were observed：levels of WBC，PLT and T cell subpopulations in blood and serum immunoglobulin(Ig) level. ［Results］ The response rate of treatment group and control group was 52.1％and 48.0％ respectively，without significant difference (P>0.05). The gastrointestinal toxicity and myelosuppression in the treatment group were alleviated as compared with the control group，with significant difference(P<0.05). Compared with the control group，CD8+ cells and CD4+ /CD8+ ratio were markedly increased in the treatment group after treatment(P<0.05) . The KPS scores and serum IgM and IgG levels were higher in the treatment group than those in the control group (P<0.05).［Conclusion］ The placenta polypeptide injection plus GP chemotherapy regimen shows better therapeutic effect，reduces adverse effects of chemotherapy and improves the quality of life in patients with NSCLC stage Ⅲ or Ⅳ. |
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