| 王 剑,马若冰,陈雪琴.晚期非小细胞肺癌患者贫血相关因素及其对预后的影响[J].肿瘤学杂志,2013,19(9):718-721. |
| 晚期非小细胞肺癌患者贫血相关因素及其对预后的影响 |
| Correlative Factors of Anemia in Advanced Non-small Cell |
| 投稿时间：2013-06-13 |
| DOI：10.11735/j.issn.1671-170X.2013.09.B012 |
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| 中文关键词: 肺肿瘤 癌性贫血 预后 |
| 英文关键词:lung neoplasms cancer-related anemia prognosis |
| 基金项目: |
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| 摘要点击次数: 2708 |
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| 中文摘要: |
| 摘 要：［目的］ 分析晚期非小细胞肺癌患者贫血发生的危险因素及贫血对预后的影响。［方法］ 统计41例晚期NSCLC患者治疗前后癌性贫血的发生率，分析其与性别、年龄、临床分期、PS评分的关系，并探讨癌性贫血对患者预后的影响。［结果］ 化疗2个周期后贫血发生率明显高于化疗前（63.4% vs 24.4%，P<0.01），贫血严重程度随着化疗周期的增加而加重。单因素分析显示临床分期、PS评分是发生癌性贫血的危险因素；临床分期、PS评分、癌性贫血是影响患者无进展生存的因素，化疗前无贫血的患者较化疗前有贫血的患者中位无进展生存明显延长，分别为4.2个月和2.6个月（P=0.005）。临床分期、癌性贫血也是影响晚期NSCLC患者生存的危险因素，化疗后并发癌性贫血的患者中位生存期较未发生癌性贫血者明显缩短，分别为15个月和26个月（P=0.001)。［结论］ 晚期NSCLC患者有较高的贫血尤其是化疗相关性贫血的发生率，无论化疗前发生的贫血还是化疗导致的贫血均严重影响患者的无进展生存和总生存。 |
| 英文摘要: |
| Abstract：［Purpose］To analyze the risk factors of anemia in patients with advanced non-small cell lung cancer (NSCLC)，and to investigate the impact of anemia on prognosis of NSCLC patients. ［Methods］ Incidence of cancer-related anemia of 41 cases with NSCLC were investigated，and its relationship with gender，age，clinical stage，PS score was analyzed，and its impact on prognosis of NSCLC patients were investigated.［Results］ The incidence of anemia after two cycles of chemotherapy was significantly higher than that before chemotherapy (63.4% vs 24.4%，P<0.01)，and the degree of anemia increased simultaneously with the cycles of chemotherapy. According to univariete analysis，clinical stage，PS score were closely related to incidence of cancer-related anemia. Clinical stage，PS score and cancer-related anemia were the risk factors of progression-free survival(PFS). Median PFS of patients without anemia before chemotherapy was significantly longer than that of patients with anemia before chemotherapy(4.2 months vs 2.6 months，P=0.005). Cancer-related anemia，clinical stage were the risk factors of overall survival(OS) of NSCLC patients. The median survival of cancer-related anemia patients post-chemotherapy was significantly shorter than that in patients without anemia post-chemotherapy (15 months vs 26 months，P=0.001).［Conclusion］ NSCLC patients had a higher incidence of anemia，especially the incidence of chemotherapy-related anemia. No matter anemia pre-chemotherapy or chemotherapy-induced anemia，both significant influence on PFS and OS in NSCLC patients. |
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