| 叶 丹,傅志超,程惠华.鼻咽癌初诊患者EB病毒与2008分期相关性的临床研究[J].肿瘤学杂志,2013,19(9):709-712. |
| 鼻咽癌初诊患者EB病毒与2008分期相关性的临床研究 |
| Clinical Research of Correlation Between EB Virus and 2008 TNM Staging in Newly Diagnosed Nasopharyngeal Carcinoma Patients |
| 投稿时间：2013-06-12 |
| DOI：10.11735/j.issn.1671-170X.2013.09.B010 |
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| 中文关键词: 鼻咽肿瘤 临床分期 EB病毒 |
| 英文关键词:nasopharyngeal neoplasms clinical staging EB virus |
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| 中文摘要: |
| 摘 要：［目的］ 探讨EB病毒（EBV）与鼻咽癌（NPC）2008分期的相关性；比较EBV IgA抗体滴度与EBV DNA拷贝数在NPC诊断与疗效评价中的差异。［方法］ 将初诊为NPC的患者98例，在放化疗前予以TNM分期；在放化疗前、后分别监测血清EBV抗体滴度与全血EBV DNA拷贝数。在放化疗后2个月，复查鼻咽部磁共振及全身检查后评价疗效。［结果］ 治疗前，血清EBV IgA抗体滴度阳性患者28例，全血EBV DNA拷贝数阳性42例。EBV IgA抗体滴度及全血EBV DNA拷贝数在不同TNM分期上差异均无统计学意义（P=0.189，P=0.074）。全血EBV DNA拷贝数在Ⅲ期与Ⅱ期、Ⅲ期与Ⅳa期间比较，差异均具有统计学意义（P=0.024，P=0.022）。放疗后，全血EBV DNA拷贝数转阴率高；但在提示转移或复发方面，EBV IgA抗体与EBV DNA比较二者差异无统计学意义（P=0.095）。［结论］ 血清EBV IgA抗体与NPC 2008分期无相关性。全血EBV DNA拷贝数与NPC 2008分期具有一定相关性。全血EBV DNA拷贝数转阴率高，优于EBV IgA抗体，在一定程度上能有效评价治疗疗效及监测病情变化。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the correlation between EB virus(EBV) and clinical TNM staging in the newly diagnosed nasopharyngeal carcinoma(NPC) patients，and to compare the difference of EBV IgA antibody titer with EBV DNA copy in the diagnosis and efficacy evaluation of NPC.［Methods］ Ninety-eight NPC patients newly diagnosed were staged according to TNM staging before radio-chemotherapy. Serous EBV IgA antibody titer and whole blood EBV DNA copy were detected before and after radio-chemotherapy. Two months after radio-chemotherapy，nasopharynx MRI and systemic examination were applied to evaluate the efficacy.［Results］ There was 28 cases with positive serous EBV IgA antibody，42 cases with positive EBV DNA copy. There was no significant difference of both EBV IgA antibody titer and EBV DNA copy in various TNM staging（P=0.189，P=0.074）.There were significant difference of EBV DNA copy between stage Ⅲ and stage Ⅱ（P=0.024），and between stage Ⅲ and Ⅳa（P=0.022）．After treatment，EBV DNA levels had a high negative conversion ratio. But no significant difference of EBV IgA antibody and EBV DNA in indicating metastasis or recurrence was found（P=0.095）.［Conclusion］ There was no correlation between serous EBV IgA antibody and 2008 TNM staging. There was certain correlation between whole blood EBV DNA copy and 2008 TNM staging. EBV DNA has a high negative conversion ratio，which is superior to EBV IgA antibody，and can effectively evaluate efficacy and monitor patient’s condition. |
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