| 郭 茜,齐秀恒,王帅兵.696例乳腺癌患者临床特点及随访分析[J].肿瘤学杂志,2013,19(9):685-689. |
| 696例乳腺癌患者临床特点及随访分析 |
| Clinical Characteristics and Follow-up of 696 Cases with Breast Cancer |
| 投稿时间：2013-07-03 |
| DOI：10.11735/j.issn.1671-170X.2013.09.B005 |
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| 中文关键词: 乳腺肿瘤 预后 随访 临床病理学 |
| 英文关键词:breast cancer prognosis follow-up clinicopathology |
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| 中文摘要: |
| 摘 要：［目的］ 探讨乳腺癌患者的临床特点及预后。［方法］ 回顾分析696例乳腺癌患者的临床特点，随访其预后及影响因素。［结果］ 随访的635例中，11.3%（72/635）死亡，其中复发转移和晚期乳腺癌占80.6%（58/72）。1、3、5年生存率分别为98.6%、94.4%和92.1%。接受术后辅助化疗和未接受的复发转移率分别为17.8%、36.5%（P＜0.01），死亡率分别为1.5%、5.8%（P＞0.05）。接受术后辅助放疗和未接受的复发转移率分别为20.9%、43.6%（P＜0.01），死亡率分别为3.4%、9.1%（P＞0.05）。初始治疗有效和无效的死亡率分别为20.8%、60.3%（P＜0.01）。Her-2表达阳性与阴性者死亡率分别为19.8%和8.4%（P＜0.01）。内分泌治疗组与未采用内分泌治疗组死亡率分别为8.1%和15.0%（P＜0.01）。三阴性乳腺癌与非三阴性乳腺癌死亡率分别为23.9%和9.2%（P＜0.01）。单发转移与多发转移死亡率分别为14.5%和57.1%（P＜0.01）。［结论］ 辅助治疗、初始治疗疗效、Her-2表达状况、内分泌治疗、三阴性乳腺癌、首次复发转移数目均影响乳腺癌预后。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the clinical characteristics and prognosis of female breast cancer．［Methods］ Clinical characteristics of 696 cases with breast cancer were analyzed retrospectively，and the prognosis and its influencing factors were analyzed． ［Results］ In 635 follow-up patients，the mortality was 11.3%(72/635). Of the 72 death cases 80.6%（58/72） were recurrent and metastatic/advanced breast cancer patients. The 1-，3- and 5-year survival rates were 98.6%，94.4% and 92.1% respectively．The recurrent/metastatic rate of patients with postoperative chemotherapy and without postoperative chemotherapy were 17.8% and 36.5% respectively（P＜0.01），and the mortalities were 1.5% and 5.8% respectively（P＞0.05）. The recurrent/metastatic rates of patients with postoperative radiotherapy and without postoperative radiotherapy were 20.9% and 43.6%（P＜0.01），and the mortalities were 3.4% and 9.1% respectively（P＞0.05）. The mortalities in chemotherapy response group and no response group were 20.8% and 60.3% respectively(P＜0.01). The mortalities of Her-2 positive patients and negative patients were 19.8% and 8.4% respectively(P＜0.01). The mortalities in patients with hormonal therapy and without hormonal therapy were 8.1% and 15% respectively(P＜0.01). The mortalities of triple negative breast cancer and non-triple negative breast cancer were 23.9% and 9.2% respectively(P＜0.01). The mortalities of patients with single metastasis and multi-recurrence and metastasis were 14.5% and 57.1% respectively（P＜0.01）. ［Conclusion］ Postoperative adjuvant therapy，the response of primary chemotherapy，Her-2 expression status，hormonal therapy，triple negative breast cancer，and number of initial recurrent lesions all influence prognosis of breast cancer. |
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