| 陆 翔,陈彩萍,邬万新.ER阳性细胞比率对乳腺癌Her-2基因状态的预测作用[J].肿瘤学杂志,2013,19(9):675-679. |
| ER阳性细胞比率对乳腺癌Her-2基因状态的预测作用 |
| Value of ER Positive Cells Proportion in Predicting of Her-2 Gene Status in Patients with Breast Cancer |
| 投稿时间：2013-07-04 |
| DOI：10.11735/j.issn.1671-170X.2013.09.B003 |
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| 中文关键词: 乳腺肿瘤 雌激素受体 人表皮生长因子受体2（Her-2） |
| 英文关键词:breast neoplasms estrogen receptor(ER) Her-２ |
| 基金项目:嘉兴市科技计划项目（2010AY1031） |
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| 摘要点击次数: 1901 |
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| 中文摘要: |
| 摘 要： ［目的］ 通过研究Her-2免疫组化检测结果为不确定（2+）的乳腺癌患者的临床病理特征，寻找预测Her-2基因状态的方法。［方法］ 纳入51例Her-2免疫组化检测结果为2+的乳腺癌患者，采用荧光原位杂交法（FISH）确定其Her-2基因状态，比较Her-2基因扩增组与未扩增组之间的临床病理特征，通过组间差异寻找预测Her-2基因状态的指标。［结果］ 51例患者中，FISH检测Her-2基因未扩增者25例，扩增者26例。Her-2基因未扩增组与扩增组间患者的年龄、肿瘤大小、淋巴结状态、TNM分期、PR状态差异无统计学意义，ER状态差异有统计学意义。ER阳性率与Her-2基因扩增呈负相关。ER阳性细胞比>75%的患者主要（83.3%，15/18）存在于Her-2基因未扩增组中，ER阳性细胞比≤75%的患者主要（69.7%，23/33）存在于Her-2基因扩增组中。［结论］ 对Her-2免疫组化检测结果为2+的乳腺癌患者中，ER阳性细胞比率可粗略预测Her-2基因的状态。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate clinicopathologic features of breast cancer patients with immunohistochemistry(IHC) Her-2 uncertain (2+)，and to explore the method of predicting the status of Her-2 gene. ［Methods］ A total of 51 patients with breast cancer whose Her-2 score was 2+ were included. Fluorescence in situ hybridization (FISH) was applied to determine the status of Her-2 gene. The clinicopathological characteristics between Her-2 gene amplification group and Her-2 gene non-amplification group were compared and to search the differences between the 2 groups for predicting Her-2 gene status.［Results］ FISH detection showed that of all the 51 patients，25 patients had no Her-2 gene amplification，while 26 patients had. As for age，tumor size，lymph node status，TNM stage and PR status，there was no statistical difference between the two groups，while statistical difference existed in ER status. ER positive was negatively correlated with Her-2 gene amplification. The patients whose ER positive cells proportion was >75% were mainly (83.3%，15/18) from Her-2 gene non-amplification group，while those ER positive cells proportion ≤ 75% was mainly (69.7%，23/33) from Her-2 gene amplification group. ［Conclusion］ For breast cancer patient whose Her-2 score 2+，ER positive cell proportion might roughly be used to predict the status of Her-2 gene. |
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