| 雍伟伟,胡新荣.YB-1调控上皮间质转化影响肿瘤的侵袭转移研究[J].肿瘤学杂志,2013,19(8):649-653. |
| YB-1调控上皮间质转化影响肿瘤的侵袭转移研究 |
| Research on YB-1 Regulating Epithelial-mesenchymal Transition to Affect Tumor Invasion and Metastasis |
| 投稿时间：2013-03-22 |
| DOI：10.11735/j.issn.1671-170X.2013.08.B014 |
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| 中文关键词: 上皮—间质转化 肿瘤 侵袭 肿瘤转移 YB-1 |
| 英文关键词:epithelial-mesenchymal transition(EMT) neoplasms invasion neoplasm metastasis Y-box binding protein-1(YB-1) |
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| 摘要点击次数: 2425 |
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| 中文摘要: |
| 摘 要：上皮间质转化(EMT)是上皮细胞向间质细胞转化的现象，在肿瘤的发生发展尤其在肿瘤的侵袭转移方面发挥了重要作用。EMT的发生与多种因子相关，最近研究表明，YB-1通过作用于EMT相关转录因子，诱导细胞通路改变，以实现对EMT的调控。因此对YB-1调控EMT机制的研究，为发展新的治疗策略提供了重要信息。全文就YB-1在EMT发生中的作用及与肿瘤侵袭转移的关系等作一综述。 |
| 英文摘要: |
| Abstract：Epithelial-mesenchymal transition (EMT) is a phenomenon of cells transform from epithelial phenotype to mesenchymal phenotype. EMT plays an important role in carcinogensis and progress for cancer，especially in the process of invasion and metastasis. Several factors alone or in combination can induce EMT. The latest research has shown that by acting on those factors to change cellular pathways，Y-box binding protein-1(YB-1) can regulate EMT. Hence，the studies on how YB-1 regulates EMT have provided vital information for developing new therapeutic strategies.This review is mainly about the role of YB-1 in the EMT development，tumor invasion and metastasis. |
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