| 黄仁华,胡 斌,沈加林.弥散张量成像在脑胶质瘤放疗中的应用价值[J].肿瘤学杂志,2013,19(8):628-631. |
| 弥散张量成像在脑胶质瘤放疗中的应用价值 |
| The Value of Diffusion Tensor Imaging in the Radiotherapy for Brain Gliomas |
| 投稿时间：2013-03-29 |
| DOI：10.11735/j.issn.1671-170X.2013.08.B009 |
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| 中文关键词: 脑胶质瘤 弥散张量成像 放射治疗 |
| 英文关键词:brain gliomas diffusion-tensor imaging radiotherapy |
| 基金项目: |
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| 摘要点击次数: 2024 |
| 全文下载次数: 990 |
| 中文摘要: |
| 摘 要：［目的］ 利用弥散张量成像探讨脑胶质瘤放疗后的早期变化。［方法］ 31例诊断明确的脑胶质瘤部分切除术后患者，在放疗前后1周内分别行MRI平扫+增强+DTI检查，分析肿瘤瘤体区及剂量相关区域的FA、ADC值变化。［结果］ 肿瘤瘤体区放疗后FA及ADC值均升高，放疗前后差异均有统计学意义（P<0.05）。剂量>60Gy时正常白质FA值放疗后升高，50~60Gy、30~40Gy、20~30Gy区域的正常白质放疗后FA值均下降，差异均无统计学意义（P>0.05）；剂量>60Gy、50~60Gy、40~50Gy、30~40Gy、20~30Gy 区域的ADC值升高，但放疗前后的差异亦无统计学意义（P>0.05）。［结论］ 放疗前、后肿瘤瘤体区FA、ADC值变化能较早提供肿瘤对放疗反应评估。 |
| 英文摘要: |
| Abstract:［Purpose］ To evaluate the value of diffusion-tensor imaging(DTI) in the radiotherapy for gliomas.［Methods］ Thirty-one patients with gliomas pathologically proved after partial surgical resection underwent routine MRI contrast-enhanced scanning and DTI pre- and post-radiotherapy(pre-RT and post-RT). The regions of interest（ROI）were placed on the central tumor region and normal-appearing white matter(NAWM). The FA and ADC values were calculated automatically from both pre-RT and post-RT image sequences.［Results］ Compared to pre-RT，FA and ADC values increased post-RT in tumor region with significant differences(P<0.05). Compared to pre-RT about NAWM，FA values inclined for dose bins >60Gy，inclined for dose bins of 50~60Gy，30~40Gy，20~30Gy groups post-RT. Neither had significant differences（P>0.05）. For dose bins >60Gy，50~60Gy，30~40Gy，20~30Gy groups，ADC values inclined post-RT，neither had significant differences（P>0.05）.［Conclusion］ DTI can early provide important information about effect of radiotherapy. |
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