黄仁华,胡 斌,沈加林.弥散张量成像在脑胶质瘤放疗中的应用价值[J].肿瘤学杂志,2013,19(8):628-631.
弥散张量成像在脑胶质瘤放疗中的应用价值
The Value of Diffusion Tensor Imaging in the Radiotherapy for Brain Gliomas
投稿时间:2013-03-29  
DOI:10.11735/j.issn.1671-170X.2013.08.B009
中文关键词:  脑胶质瘤  弥散张量成像  放射治疗
英文关键词:brain gliomas  diffusion-tensor imaging  radiotherapy
基金项目:
作者单位
黄仁华 上海交通大学医学院附属仁济医院 
胡 斌 上海交通大学医学院附属仁济医院 
沈加林 上海交通大学医学院附属仁济医院 
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中文摘要:
      摘 要:[目的] 利用弥散张量成像探讨脑胶质瘤放疗后的早期变化。[方法] 31例诊断明确的脑胶质瘤部分切除术后患者,在放疗前后1周内分别行MRI平扫+增强+DTI检查,分析肿瘤瘤体区及剂量相关区域的FA、ADC值变化。[结果] 肿瘤瘤体区放疗后FA及ADC值均升高,放疗前后差异均有统计学意义(P<0.05)。剂量>60Gy时正常白质FA值放疗后升高,50~60Gy、30~40Gy、20~30Gy区域的正常白质放疗后FA值均下降,差异均无统计学意义(P>0.05);剂量>60Gy、50~60Gy、40~50Gy、30~40Gy、20~30Gy 区域的ADC值升高,但放疗前后的差异亦无统计学意义(P>0.05)。[结论] 放疗前、后肿瘤瘤体区FA、ADC值变化能较早提供肿瘤对放疗反应评估。
英文摘要:
      Abstract:[Purpose] To evaluate the value of diffusion-tensor imaging(DTI) in the radiotherapy for gliomas.[Methods] Thirty-one patients with gliomas pathologically proved after partial surgical resection underwent routine MRI contrast-enhanced scanning and DTI pre- and post-radiotherapy(pre-RT and post-RT). The regions of interest(ROI)were placed on the central tumor region and normal-appearing white matter(NAWM). The FA and ADC values were calculated automatically from both pre-RT and post-RT image sequences.[Results] Compared to pre-RT,FA and ADC values increased post-RT in tumor region with significant differences(P<0.05). Compared to pre-RT about NAWM,FA values inclined for dose bins >60Gy,inclined for dose bins of 50~60Gy,30~40Gy,20~30Gy groups post-RT. Neither had significant differences(P>0.05). For dose bins >60Gy,50~60Gy,30~40Gy,20~30Gy groups,ADC values inclined post-RT,neither had significant differences(P>0.05).[Conclusion] DTI can early provide important information about effect of radiotherapy.
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