| 陈真云,盛修贵,李秀敏.SCCAg、CYFRA21-1、CEA联合检测在中晚期及复发宫颈鳞癌诊断和治疗中的临床价值[J].肿瘤学杂志,2013,19(8):595-599. |
| SCCAg、CYFRA21-1、CEA联合检测在中晚期及复发宫颈鳞癌诊断和治疗中的临床价值 |
| Clinical Value of SCCAg，CYFRA21-1 and CEA Detection on Diagnosis and Treatment for Advanced or Recurrent Cervical Squamous Cell Cancer |
| 投稿时间：2013-01-11 |
| DOI：10.11735/j.issn.1671-170X.2013.08.B003 |
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| 中文关键词: 宫颈肿瘤 鳞状细胞癌 同步放化疗 SCCAg CYFRA21-1 CEA 复发 预后 |
| 英文关键词:cervical neoplasms squamous cell cancer concurrent chemoradiotherapy SCCAg CYFRA21-1 CEA recurrence prognosis |
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| 中文摘要: |
| 摘 要：［目的］ 探讨血清鳞状细胞癌肿瘤相关抗原（SCCAg）、细胞角蛋白19片段抗原21-1（CYFRA21-1）、癌胚抗原（CEA）对判断中晚期宫颈鳞癌同步放化疗疗效及在复发宫颈癌诊断、治疗和预后评估中的作用。［方法］ 随机选取468例接受同步放化疗的中晚期宫颈鳞癌患者(KPS≥70分)，检测患者同步放化疗前后血清中SCCAg、CYFRA21-1、CEA的水平变化。比较复发转移者与未复发转移者，以及复发转移者治疗前后血清中SCCAg、CYFRA21-1、CEA的变化情况。［结果］ SCCAg、CYFRA21-1、CEA联合检测较单项检测诊断中晚期宫颈癌的灵敏度明显提高（P＜0.05），灵敏度随临床分期的进展而升高，差异有统计学意义（P＜0.05）；放化疗后，患者血清中SCCAg、CYFRA21-1、CEA水平均明显下降，其差异有显著统计学意义（P＜0.001）。复发及转移患者较无瘤生存患者血清中SCCAg、CYFRA21-1、CEA的水平明显升高，差异有统计学意义（P＜0.001）；复发患者治疗后完全缓解（CR）及部分缓解(PR)者血清中SCCAg、CYFRA21-1、CEA较治疗前明显降低，差异有统计学意义（P＜0.05），稳定（SD)及病情进展（PD)患者，治疗前后比较差异无统计学意义（P＞0.05）。［结论］ SCCAg、CYFRA21-1和CEA联合检测对中晚期宫颈癌及复发宫颈癌的诊断、疗效评价、预后预测及病情监测有一定的临床价值。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the clinical value of SCCAg，CYFRA21-1 and CEA on the diagnosis and monitoring prognosis for advanced squamous cell cervical cancer after concurrent chemoradiotherapy.［Methods］ Four hundreds and sixty-eight patients with advanced cervical squamous cell carcinoma were enrolled(KPS≥70).All patients underwent serum SCCAg，CYFRA21-1 and CEA detection before treatment and after treatment. The sensitivity of SCCAg，CYFRA21-1 and CEA as diagnostic indexes were analyzed. ［Results］ The sensitivity of combined detection of SCCAg，CYFRA21-1 and CEA was significantly higher than that of single marker in advanced cervical squamous cell cancer（P<0.05）.The sensitivity of SCCAg，CYFRA21-1 and CEA in patients with stage Ⅲ or Ⅳ were significantly higher than that in patients with stage Ⅱb（P<0.05）. The serum levels of SCCAg，CYFRA21-1 and CEA significantly decreased after chemoradiotherapy（P<0.001）. The serum levels of SCCAg，CYFRA21-1 and CEA were significantly higher in recurrent or/and metastatic patients than those in disease-free patients（P<0.001），but significantly decreased in patients with complete remission (CR) and partial remission(PR) after chemoradiotherapy(P<0.05). ［Conclusions］ The combined detection of SCCAg，CYFRA21-1 and CEA is helpful for the diagnosis and monitoring prognosis in advanced squamous cell cervical cancer and recurrence cervical cancer. |
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