| 闫效宇,朱彦丽,王 敏.AKT1与卵巢浆液性肿瘤发生发展及化疗耐药的关系研究[J].肿瘤学杂志,2013,19(8):590-594. |
| AKT1与卵巢浆液性肿瘤发生发展及化疗耐药的关系研究 |
| Relationship of AKT1 with Occurrence and Chemo-resistance in Ovarian Serous Neoplasms |
| 投稿时间：2013-04-19 |
| DOI：10.11735/j.issn.1671-170X.2013.08.B002 |
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| 中文关键词: 卵巢肿瘤 AKT1 浆液性肿瘤 化疗耐药 |
| 英文关键词:ovarian neoplasms AKT1 serous neoplasms chemoresistance |
| 基金项目:国家自然科学基金资助项目（30973189） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨AKT1的表达与卵巢浆液性肿瘤发生发展及卵巢癌化疗耐药的关系。 ［方法］ 免疫组织化学SP法检测67例卵巢浆液性腺癌（其中化疗耐药30例、化疗敏感37例）、10例卵巢交界性浆液性囊腺瘤、10例卵巢良性浆液性囊腺瘤和10例正常卵巢组织中的AKT1表达情况。［结果］ AKT1的阳性表达率在卵巢浆液性腺癌、卵巢交界性浆液性囊腺瘤、卵巢良性浆液性囊腺瘤和正常卵巢组织中分别为62.69%、70.00%、40.00%和0，有显著统计学差异（P=0.001），在化疗耐药卵巢浆液性腺癌中明显高于化疗敏感者（P=0.033）。AKT1的阳性表达率在Ⅰ～Ⅱ期和Ⅲ～Ⅳ期卵巢浆液性腺癌中分别为31.58%和75.00%，有显著统计学差异（P=0.001）。AKT1的阳性表达率与卵巢浆液性腺癌患者绝经状态、组织学分级和淋巴结转移情况无关（P>0.05）。［结论］ AKT1与卵巢浆液性肿瘤发生发展和卵巢癌化疗耐药有关，可作为预后和化疗耐药性的间接预测指标之一。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the relationship of AKT1 with occurrence and chemoresistance in ovarian serous neoplasms.［Methods］ AKT1 expression in 67 cases with ovarian serous cystadenocarcinoma (30 cases，chemotherapy resistance；37 cases，chemotherapy sensitivity)，10 cases with ovarian borderline serous cystadenoma，10 cases with ovarian serous cystadenoma and 10 cases normal ovarian tissues were detected immonohistochemically. ［Results］ The positive rates of AKT1 in ovarian serous cystadenocarcinoma，ovarian borderline serous cystadenoma，ovarian serous cystadenoma and normal ovarian tissues were 62.69%，70.00%，40.00% and 0 respectively，with significant difference(P=0.001). The positive rate of AKT1 in chemotherapy resistance ovarian serous cystadenocarcinoma was significantly higher than that in chemotherapy sensitive ovarian serous cystadenocarcinoma(P=0.033). The positive rates of AKT1 in ovarian serous cystadenocarcinoma stage Ⅰ～Ⅱ and Ⅲ～Ⅳ were 31.58% and 75.00%，respectively，with significant difference(P=0.001). The positive rate of AKT1 did not correlate with menopausal status，histological grade and lymph node metastasis(P>0.05).［Conclusion］ AKT1 correlates with occurrence and chemoresistance in ovarian serous cancer. It may be considered as a marker for predicting prognosis and chemoresistance. |
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