| 余晶晶,梁 伟,周 军.非典型脑膜瘤的临床病理特点及预后分析[J].肿瘤学杂志,2013,19(7):553-557. |
| 非典型脑膜瘤的临床病理特点及预后分析 |
| Clinicopathologic Features and Prognostic Analysis of Atypical Meningiomas |
| 投稿时间：2013-03-18 |
| DOI：10.11735/j.issn.1671-170X.2013.07.B011 |
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| 中文关键词: 非典型脑膜瘤 临床病理学 预后 |
| 英文关键词:atypical meningioma clinicopathology prognosis |
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| 中文摘要: |
| 摘 要：［目的］ 探讨非典型脑膜瘤（AM）的临床病理学特点及预后相关因素。［方法］ 回顾性分析54例AM的临床病理资料，并根据随访结果将患者分成死亡复发组和无死亡复发组，对两组患者的8项临床病理学指标进行统计分析。［结果］ 54例AM患者中位年龄58岁，次全切除8例。30例肿瘤最大径≥5cm，17例见肿瘤侵犯脑组织，13例核分裂≥4/10HPF，32例可见肿瘤组织自发性坏死，26例肿瘤细胞有明显核仁，Ki-67指数平均为7.04%。36例无复发存活，7例复发，11例死亡。上述8项指标在两组之间的差异均具有统计学意义（P<0.05）。［结论］肿瘤最大径≥5cm、未被完全切除、肿瘤侵犯脑组织、有自发性坏死、瘤细胞有显著核仁、核分裂≥4/10HPF、Ki-67指数≥7%是非典型脑膜瘤患者复发或死亡的危险因素。 |
| 英文摘要: |
| Abstract: ［Purpose］ To investigate the clinicopathologic characteristics of atypical meningioma(AM) and the relevant prognostic factors. ［Methods］ Clinicopathologic data of 54 cases with AM were retrospectively reviewed. On the basis of follow-up data，patients were divided into two groups:recurrence or death group and recurrence-free survival group. Eight clinicopathologic parameters related to recurrence or death were evaluated in each patient. ［Results］ Of the 54 cases，median age was 58 years old，8 cases were subtotal resection. The maximum diameter of 30 cases were ≥5cm. Brain invasion occurred in 17 cases. There were 13 cases with mitotic figures ≥4/10HPF，32 cases with spontaneous necrosis，26 cases with distinct nucleoli，and the mean index of Ki-67 was 7.04%. Thirty-six cases were recurrence-free survival;7 cases，recurred；and 11 cases，died. There were 8 clinicopathologic parameters with significant difference between the two groups(P<0.05). ［Conclusion］ Tumor size ≥5cm in diameter，subtotal resection，brain invasion，spontaneous necrosis，distinct nucleolus，more than 4/10HPF in mitotic figures and 7% in Ki-67 index are the risk factors related to recurrence or death in the patients with AM. |
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