车爱文,陈淑苹,康凯夫.EZH2和FHIT在肝癌中的表达及其临床意义[J].肿瘤学杂志,2013,19(7):514-517. |
EZH2和FHIT在肝癌中的表达及其临床意义 |
Expressions of EZH2 and FHIT Protein in Primary Human Hepatocellular Carcinoma and Their Clinical Significance |
投稿时间:2012-12-24 |
DOI:10.11735/j.issn.1671-170X.2013.07.B003 |
|
|
中文关键词: 果蝇zeste 基因增强子同源物2 脆性组氨酸三联体基因 肝肿瘤 免疫组化 |
英文关键词:enhancer of zeste homolog 2(EZH2) fragile histidine triade(FHIT) liver neoplasms immunhistochemistry |
基金项目: |
|
摘要点击次数: 3298 |
全文下载次数: 1605 |
中文摘要: |
摘 要:[目的] 探讨果蝇zeste基因增强子同源物2(EZH2)和脆性组氨酸三联体 (FHIT) 蛋白在原发性肝细胞性肝癌(HCC)组织中的表达,及其在肝癌发生发展过程中的作用和临床病理学意义。[方法] 应用免疫组化S-P法检测50例原发性肝细胞性肝癌、30例肝硬化、10例正常肝组织中EZH2、FHIT蛋白的表达。[结果] FHIT蛋白在HCC中的表达明显低于肝硬化和正常肝组织,阳性表达率分别是40.00%(20/50)、80.00%(24/30)、80.00%(8/10),三者之间具有明显的差异性(χ2=15.74,P<0.05);HCC、肝硬化和正常肝组织中EZH2蛋白阳性表达率分别是88.00%(44/50)、46.67%(14/30)、30.00%(3/10),三者之间的差异有统计学意义(χ2=20.63,P<0.05),且EZH2蛋白在HCC组织中的表达明显高于肝硬化和正常肝组织中的表达(χ2=16.07,χ2=14.07,P均<0.05)。[结论] EZH2蛋白在肝癌中的表达增加与 FHIT蛋白相关,提示肝癌中 EZH2蛋白与FHIT蛋白可能相互协调,促进肝癌的发生发展。 |
英文摘要: |
Abstract:[Purpose] To explore the expressions of EZH2 and FHIT protein in primary human hepatocellular carcinoma(HCC)and their clinicopathological significance. [Methods] The expressions of EZH2 and FHIT protein in 50 cases with HCC,30 cases with liver cirrhosis and 10 cases with normal liver tissues were assessed by immunohistochemical S-P method. [Results] The expression of FHIT protein in cancer tissues was lower than that in cirrhosis tissues and normal tissues,and the positive rates were 40.00%(20/50),80.00%(24/30),80.00%(8/10)respectively,with significant difference(χ2=15.74,P<0.05);The positive rates of EZH2 protein in cancer tissues,cirrhosis tissues,normal tissues were 88.00%(44/50),46.67%(14/30),30.00%(3/10)respectively,also with significant difference(χ2=20.63,P<0.05).The expression of EZH2 protein in cancer tissues was higher than that in cirrhosis tissues and normal tissues(χ2=16.07,χ2=14.07,P<0.05). [Conclusion] The increased expression of EZH2 protein is closely associated with FHIT protein in HCC; EZH2 and FHIT protein may have mutual coordination to promote HCC development. |
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |