| 陈 超,王佳峰,赵坚强.颌下腺癌在多形性腺瘤中预后因素分析[J].肿瘤学杂志,2013,19(6):461-465. |
| 颌下腺癌在多形性腺瘤中预后因素分析 |
| Prognostic Factors of Carcinoma ex Pleomorphic Adenoma (CXPA) from Submandibular Gland |
| 投稿时间：2013-03-11 |
| DOI：10.11735/j.issn.1671-170X.2013.06.B011 |
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| 中文关键词: 涎腺肿瘤 颌下腺 癌在多形性腺瘤中 预后 |
| 英文关键词:salivary gland neoplasms submandibular gland carcinoma ex pleomorphic adenoma prognosis |
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| 中文摘要: |
| 摘 要：［目的］ 分析颌下腺起源的癌在多形性腺瘤中（CXPA）的预后及其影响因素，探讨其合理治疗。［方法］ 回顾性分析25例颌下腺起源的CXPA的临床及随访资料。所有患者均行原发灶根治性手术切除，8例接受了术后放疗。［结果］ 全组复发转移率为52.0%，5年总体生存率和肿瘤相关生存率分别为48.0%和53.9%。单因素分析结果显示病理分级、T分期、淋巴结转移和临床分期对颌下腺CXPA生存率的影响有统计学意义（P<0.05），侵袭性对生存率的影响接近有统计学意义（P=0.092）。COX多因素分析显示：淋巴结转移与颌下腺CXPA的生存率有关（P<0.05）。［结论］ 淋巴结转移是颌下腺CXPA的独立预后因素。根治性手术以及合理的术后放疗是其治疗的主要方法。 |
| 英文摘要: |
| Abstract: ［Purpose］ To investigate the prognostic influencing factors of carcinoma ex pleomorphic adenoma (CXPA) arisen from submandibular gland，and the reasonable treatment for it. ［Methods］ Clinical and following-up data of 25 cases with CXPA of submandibular gland were analyzed retrospectively All the cases underwent radical resection and in which 8 cases accepted postoperative radiotherapy. ［Results］ The overall recurrence was 52.0%，and 5-year overall survival and tumor-related survival were 48.0% and 53.9% respectively. Univariate analysis showed that histological grading，T staging，lymph node metastasis and clinical staging were prognostic influencing factors with statistical significance(P<0.05). Invasiveness seemed impacting on prognosis but without statistical significance(P=0.092). COX multivariate analysis showed that lymph node metastasis had impact on CXPA’s survival(P<0.05). ［Conclusion］ Lymph node metastasis is an independent prognostic factor for CXPA of submandibular gland. Radical resection and reasonable postoperative radiotherapy are the predominant treatment methods. |
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