| 唐 涛,费素娟,刘军权.PPAR-γ通路在尼美舒利抑制胃癌小鼠癌细胞生长中的作用[J].肿瘤学杂志,2013,19(5):327-331. |
| PPAR-γ通路在尼美舒利抑制胃癌小鼠癌细胞生长中的作用 |
| Role of PPAR-γ Pathway in Tumor Growth Inhibition Induced by Nimesulide in Mice with Gastric Cancer |
| 投稿时间：2012-12-24 |
| DOI：10.11735/j.issn.1671-170X.2013.05.B2012634 |
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| 中文关键词: 胃肿瘤 移植瘤 PPAR-γ 尼美舒利 肿瘤生长 |
| 英文关键词:stomach neoplasms transplantation tumor PPAR-γ nimesulide tumor growth |
| 基金项目:江苏省徐州市科技局社会发展项目 (X20052321) |
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| 中文摘要: |
| 摘 要：［目的］ 研究尼美舒利(NIM)是否通过过氧化物酶增殖物激活受体γ（PPAR-γ）途径影响胃癌细胞体内生长。［方法］ 通过培养人胃癌SGC-7901细胞，建立裸鼠胃癌移植瘤模型。设立GW9662+NIM组、生理盐水组、GW9662组、NIM组共4组。3周后测量各组裸鼠移植瘤体积，并采用免疫组化法检测裸鼠移植瘤组织PPAR-γ表达。［结果］ NIM组裸鼠移植瘤体积较生理盐水组明显小，而GW9662+NIM组较NIM组移植瘤体积大，各组之间差异有显著性(P<0.05)。GW9662+NIM组与NIM组相比，移植瘤组织的PPAR-γ蛋白表达降低。［结论］ 尼美舒利在体内能抑制胃癌细胞的生长，PPAR-γ通路可能在此过程中发挥重要作用。 |
| 英文摘要: |
| Abstract:［Purpose］ To study the role of PPAR-γ pathway in tumor growth inhibition induced by nimesulide (NIM) in stomach cancer cells in vivo. ［Methods］ Nude BABL/c mice were implanted with SGC-7901 as human gastric cancer xenograft model，which were randomly divided into 4 groups: control group，GW9662 group，NIM group and GW9662+NIM group. The volume of transplantation tumors was measured and the expression of PPAR-γ protein was detected by immunohistochemistry after three weeks. ［Results］ The volume of transplantation tumors in nude mice in NIM group was smaller than that in the control group， but the volume of transplanted tumor in GW9662+NIM group was bigger than that in the NIM group. There was signifi-cantly different among the 4 groups (P<0.05). Compared with NIM group，the expression of PPAR-γ protein in transplanted tumor decreased obviously in GW9662+NIM group. ［Conclusion］ Nimesulide is capable of inhibiting tumor growth in nude mice. PPAR-γ pathway may play an important role in this process. |
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