| 卓文方,朱建东,张筱骅.纳米炭在结直肠癌术中淋巴示踪的应用[J].肿瘤学杂志,2013,19(3):210-214. |
| 纳米炭在结直肠癌术中淋巴示踪的应用 |
| Application of Carbon Nanoparticles to the Operative Lymphatic Tracer for Colorectal Carcinoma |
| 投稿时间：2012-12-20 |
| DOI：10.11735/j.issn.1671-170X.2013.03.B2012631 |
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| 中文关键词: 淋巴示踪 结直肠肿瘤 纳米炭 |
| 英文关键词:lymphatic tracer colorectal neoplasms carbon nanoparticles |
| 基金项目:温州市2012年度医药卫生科学研究项目计划A类（2012A015） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨纳米炭淋巴示踪剂在结直肠癌手术中的应用价值。［方法］将55例结直肠癌患者随机分为实验组（26例）和对照组（29例）。实验组于术中在癌旁周缘分4~6点浆膜下注射纳米炭注射液1ml，术中参考黑染的淋巴结适当调整淋巴清扫范围，解剖标本，取出淋巴结并依据黑染与否、淋巴结位置及大小分组，送检病理检查。［结果］ 标本中可见淋巴结有广泛的不同程度的黑染，实验组平均每例检获的淋巴结数、淋巴结转移率、直径<3mm的淋巴结检出率等均显著高于对照组；区域外黑染淋巴结取出活检均呈阴性。［结论］ 术中应用纳米炭注射液能明显提高淋巴结检获的数量，最大可能地清除转移的淋巴结，指导病理分期，同时清扫范围外的黑染淋巴结均呈阴性，对结直肠癌过大范围的淋巴清扫提出疑问，因此对结直肠癌的淋巴清扫术有一定的指导意义。 |
| 英文摘要: |
| Abstract:［Purpose］ To explore the value of carbon nanoparticles on the operative lymphatic tracer for colorectal carcinoma.［Methods］ Fifty-five patients with colorectal carcinoma were randomized into two groups：experimental group(26 cases) and control group(29 cases)．For the experimental group，a total of 1ml carbon nanoparticles was injected at 4~6 locations sub-serously around the cancerous site，and intraoperative stained lymph nodes were used as markers to guide lymphadenectomy in the colorectal radical procedure．Specimens were carefully dissected，then the lymph nodes were divided according to dyed or not，the lymph node position and size. At last，pathological examination applied to all lymph nodes.［Results］ Various degrees of stained lymph nodes were seen in specimens. In experimental group，the number of lymph nodes，metastatic lymph nodes per case，the rate of lymph nodes which diameter <3mm were obviously higher than those in control group. Dyed lymph nodes outside the radical resection area were proved negative pathologically.［Conclusion］ Intraoperative application of carbon nanoparticles can obviously increase the number of dissected lymph node with highest possibility to dissect metastatic lymph nodes，and guide pathological stage. The dyed lymph nodes outside the radical resection area are all negative，which challenge the over extended lymphadenectomy in radical surgery for colorectal carcinoma. Intraoperative application of carbon nanoparticles can significantly enhance lymph node clearance for colorectal carcinoma with predominate guiding significance． |
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