| 赖淑贞,刘洪波,余晓文.巨块型宫颈癌术前252锎中子后装放疗的临床观察[J].肿瘤学杂志,2013,19(3):215-218. |
| 巨块型宫颈癌术前252锎中子后装放疗的临床观察 |
| Clinical Observation on Preoperative 252-Californium Brachytherapy for Bulky Cervical Cancer |
| 投稿时间：2012-12-11 |
| DOI：10.11735/j.issn.1671-170X.2013.03.B2012607 |
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| 中文关键词: 宫颈肿瘤 放射疗法，腔内 外科手术 |
| 英文关键词:cervical neoplasms radiotherapy,intracavitary surgery |
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| 中文摘要: |
| 摘 要:［目的］ 研究252锎（252Cf）中子腔内后装放疗在巨块型宫颈癌术前辅助放疗中的作用。［方法］ 收集2007年1月至2012年6月接受根治性手术治疗的Ⅰb~Ⅱa期宫颈癌病例共102例，术前放疗组33例，宫颈肿瘤直径≥4cm，术前接受252Cf腔内后装放疗；直接手术组69例，宫颈肿瘤直径＜4cm，未接受术前辅助治疗。［结果］ 术前252Cf中子腔内后装放疗的有效率为90.9%，病理完全缓解率24.2%。术前放疗组与直接手术组比较，手术时间为(4.3±1.0)h vs (4.2±0.9)h，术后尿潴留发生率为18.2% vs 18.8%，差异无统计学意义(P＞0.05)；术前放疗组术中出血量增多，(784.9±537.0)ml vs (578.9±311.4)ml，差异具有统计学意义（P＜0.05）。［结论］ 巨块型宫颈癌术前252Cf中子腔内后装放疗的有效率高，部分达到病理缓解，不良反应可以接受，对远期疗效的影响有待随访观察。 |
| 英文摘要: |
| Abstract:［Purpose］ To assess the role of 252Californium(252Cf) brachytherapy in preoperative radiotherapy on bulky cervical cancer. ［Methods］ One hundred and two patients with cervical cancer stage Ib～IIa treated by radical hysterectomy between January 2007 and June 2012 were included in this study. Of the 102 patients，33 cases with tumor size ≥4cm received preoperative 252Cf brachytherapy，and 69 cases with tumor size ＜4cm received surgery without preoperative radiotherapy. ［Results］ The response rate of preoperative 252Cf brachytherapy was 90.9%，with a pathological complete remission (pCR) rate of 24.2%. The operating times were not significantly different between the preoperative 252Cf brachytherapy group and the surgery alone group (4.3±1.0h vs 4.2±0.9h，P＞0.05)，also the incidence of urinary retention (18.2% vs 18.8%，P＞0.05). The preoperative 252Cf brachytherapy group had significantly more mean intra-operative blood loss compared with the surgery alone group (784.9±537.0ml vs 578.9±311.4ml，P<0.05)．［Conclusion］ The 252Cf brachytherapy is effective in the preoperation therapy for bulky cervical carcinoma with tolerable toxicity. But the long term response of preoperative 252Cf brachytherapy needs further investigation． |
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