| 方学辉,吴 倩,韩雪梅.熊果酸抗小鼠H22肝癌移植瘤及对免疫功能的影响[J].肿瘤学杂志,2013,19(3):199-201. |
| 熊果酸抗小鼠H22肝癌移植瘤及对免疫功能的影响 |
| Anti-tumor and Immune Effects of Ursolic Acid on H22 Xenograft Growth in Mice |
| 投稿时间：2012-12-10 |
| DOI：10.11735/j.issn.1671-170X.2013.03.B2012602 |
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| 中文关键词: 熊果酸 氟尿嘧啶 肝肿瘤 免疫功能 |
| 英文关键词:ursolic acid 5-fluorouracil hepatocellular neoplasms immune function |
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| 中文摘要: |
| 摘 要：［目的］研究熊果酸（UA）对小鼠H22肝癌移植瘤的抑制作用及免疫功能的影响。［方法］采用移植性H22肝癌小鼠模型，随机分为模型组（对照）、氟尿嘧啶（5-Fu）处理组、UA高、低剂量组，分别连续腹腔注射5-Fu(25mg/kg)、UA(50mg/kg、25mg/kg) 14d后，处死小鼠，计算抑瘤率、外周血白细胞数、脾脏指数、胸腺指数、白细胞介素2(IL-2)、肿瘤坏死因子α(TNF-α)等指标，分析UA对小鼠H22肝癌移植瘤的生长抑制作用及免疫功能的影响。［结果］与模型组相比，UA高、低剂量组能显著减少移植瘤瘤重，其抑瘤率分别为51.03%、32.54%，差异有显著性（P<0.01，P<0.05）。UA高剂量组与5-Fu组抑瘤率（71.33%）比较，差异没有显著性 (P>0.05)。UA各组可不同程度地升高荷瘤小鼠的外周血白细胞数和脾脏指数、胸腺指数，同时还能提高荷瘤小鼠血清中TNF-α的水平(P<0.05) 。［结论］熊果酸能明显抑制H22荷瘤小鼠的肿瘤生长，其作用可能与增强机体的免疫功能有关。 |
| 英文摘要: |
| Abstract:［Purpose］ To study the anti-tumor and immune effects of ursolic acid on H22 xenograft growth in mice. ［Methods］ Transplanted H22 heptoma model in mice were applied and randomly divided into model control group，5-fluorouracil(5-Fu) treatment group，ursolic acid(UA) high-dose group and low-dose group. After 14d treatment of continuous intraperitoneal injection of 5-Fu(25mg/kg)，UA(50mg/kg，25mg/kg)，mice were sacrificed. The tumor inhibiton rate，the count of peripheral white blood cells，index of thymus and spleen were calculated. The level of interleukin-2(IL-2) and tumor necrosis factor(TNF-α) in serum were measured by radioimmunoossy. ［Results］ Compared with the model group，UA high-dose group and low-dose group can significantly reduce the xenograft tumor weight. The tumor inhibition rates were 51.03%(P<0.01)，32.54%(P<0.05). Compared with UA high-dose group，the inhibition rate of 5-Fu group(71.33%) had no significant difference(P>0.05). The UA groups can increase the white blood cell count，thymus index and spleen index at different degree，while improve the level of TNF-α in the serum of xenograft tumor mice(P<0.05). ［Conclusion］ Ursolic acid can significantly inhibit tumor growth of H22 xenograft mice，which may correlate with the enhancement of immune function. |
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