| 张彦惠,鲍建昌,邱法鹏.c-Met、HIF-1α在甲状腺乳头状癌中的表达及临床意义[J].肿瘤学杂志,2013,19(1):55-59. |
| c-Met、HIF-1α在甲状腺乳头状癌中的表达及临床意义 |
| Expressions of c-Met and HIF-1α in Thyroid Papillary Carcinoma and Their Clinical Significance |
| 投稿时间：2012-12-06 |
| DOI：10.11735/j.issn.1671-170X.2013.01.B2012595 |
|
 |
| 中文关键词: 甲状腺肿瘤 乳头状癌 c-Met HIF-1α 免疫组织化学 |
| 英文关键词:thyroid neoplasms papillary carcinoma c-Met HIF-1α immunohistochemistry |
| 基金项目: |
|
| 摘要点击次数: 2033 |
| 全文下载次数: 1219 |
| 中文摘要: |
| 摘 要：［目的］ 探讨甲状腺乳头状癌中c-Met、HIF-1α的表达及其临床意义。［方法］ 采用免疫组化方法研究c-Met、HIF-1α在甲状腺乳头状癌肿瘤组织中的表达及与临床病理特征的关系。［结果］ c-Met、HIF-1α在甲状腺乳头状癌中的阳性表达率分别为97.22%、86.11%，明显高于甲状腺腺瘤及癌旁组织，差异有统计学意义（P＜0.05），二者的高表达呈正相关，但与肿瘤大小、临床分期及淋巴结转移无关。 ［结论］ c-Met、HIF-1α在甲状腺乳头状癌癌组织中表达上调，二者表达呈正相关。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the expression of c-Met and HIF-1α in thyroid papillary carcinoma and their clinical significance. ［Methods］ The expressions of c-Met and HIF-1α in tissue samples from 36 cases with thyroid papillary carcinoma were detected by immunohistochemical staining， and their relationship with clinicopathologic characteristics were analyzed. ［Results］ The positive expression rates of c-Met and HIF-1α in thyroid papillary carcinoma tissues were 97.22% and 86.11% respectively， which were significant higher than those in cancer adjacent tissues or adenoma tissues(P＜0.05). Expressions of c-Met and HIF-1α showed a positive correlation， but no correlation of their expressions with tumor size， clinical stages or lymph node metastasis. ［Conclusion］ The expressions of c-Met and HIF-1α upregulate in thyroid papillary carcinoma tissues， with positive correlation. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |