| 汪永旭,蒋伟丰,朱陈宏.STAT3和VEGF-C在甲状腺癌中表达及其与临床病理特征关系[J].肿瘤学杂志,2013,19(2):118-121. |
| STAT3和VEGF-C在甲状腺癌中表达及其与临床病理特征关系 |
| Expressions of STAT3 and VEGF-C in Thyroid Carcinoma and Their Relationship with Clinicopathological Characteristics |
| 投稿时间：2012-11-16 |
| DOI：10.11735/j.issn.1671-170X.2013.02.B2012555 |
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| 中文关键词: 甲状腺肿瘤 信号转导和转录激活因子3 血管内皮生长因子C |
| 英文关键词:thyroid neoplasms STAT3 vascular endothelial growth factor(VEGF)-C |
| 基金项目:温岭市科技计划资助基金（温科2011wlca0067） |
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| 中文摘要: |
| 摘 要:［目的］ 探讨STAT3、VEGF-C在甲状腺癌中表达及其与临床病理特征关系。［方法］ 采用免疫组化SP技术，检测STAT3及VEGF-C在90例甲状腺癌、30例甲状腺腺瘤和瘤旁正常甲状腺组织中表达，分析其与甲状腺癌临床病理特征关系。［结果］ 在正常甲状腺组织、甲状腺腺瘤组织及甲状腺乳头状癌组织中，STAT3、VEGF-C表达阳性率逐渐增加，其差异均有统计学意义（P＜0.01），且两者存在正相关(r= 0.704，P＜0.01)。STAT3在甲状腺癌中表达在不同患者年龄、肿瘤大小、肿瘤包膜侵犯、淋巴结转移、临床分期及肿瘤多灶性方面差异有统计学意义。VEGF-C在甲状腺癌中表达在不同甲状腺癌大小、肿瘤包膜侵犯、淋巴结转移及肿瘤多灶性方面差异有统计学意义。［结论］ 对甲状腺癌进行STAT3和VEGF-C检测，有助于判断肿瘤的侵袭和转移情况。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the expressions of STAT3 and VEGF-C in thyroid carcinoma and Their relationship with clinicopathological characteristics.［Methods］ STAT3 and VEGF-C were detected immunohistochemically in thyroid cancer tissues (90 cases)，thyroid adenoma tissues(30 cases) and thyroid tissues adjacent to adenoma. The relationship between STAT3，VEGF-C expressions and clinicopathological characteristics in thyroid cancer was analyzed. ［Results］ In normal thyroid tissue，thyroid adenoma tissue and thyroid carcinoma tissue，positive rates of both of STAT3 and VEGF-C gradually increased，with significant difference(P＜0.01)，and there was a positive correlation between the expressions of the two proteins (r=0.704，P＜0.01). The expression of STAT3 in thyroid carcinoma was significantly different for patients with different status of ages，tumor sizes，capsular invasion，lymph node metastasis，clinical stages，and multifocus of tumor(P＜0.05). The expression of VEGF-C in thyroid carcinoma was significantly different in patients with different status of tumor sizes，capsular invasion，lymph node metastasis，and multifocus of tumor (P＜0.05). ［Conclusion］ Detection of STAT3 and VEGF-C expressions in thyroid carcinoma help to predict cancer invasion and metastasis. |
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