| 中文关键词: 凋亡 放疗 TRAIL 肿瘤 治疗 |
| 英文关键词:apoptosis radiotherapy TRAIL neoplasms treatment |
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| 中文摘要: |
| 摘 要：肿瘤坏死因子相关诱导凋亡配体（TRAIL）是肿瘤坏死因子（TNF）家族的新成员，具有广谱、高效、安全的抗肿瘤作用。在临床前的体外实验及移植瘤中，其与放疗联合显示出协同抗肿瘤效应和良好的安全性，具有广阔的临床应用前景。文章就TRAIL的分子生物学特性、放疗与TRAIL联合模式及其优势作一综述。 |
| 英文摘要: |
| Abstract: Tumor necrosis factor related apoptosis-inducing ligand(TRAIL) is a new member of TNF super family，with broad，efficient and safe antitumor activity. It has showed synergistic and safe antitumor effect while TRAIL combined with radiotherapy in the preclinical experiment in vitro and in vivo，with a wide prospect in clinic. The molecular biological characteristics of TRAIL，the combination mode of radiotherapy and the superiority were reviewed in this paper. |
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