| 马秀梅,叶 明,陈海燕.MRI和PET-CT对放疗后鼻咽癌颅底复发的诊断价值[J].肿瘤学杂志,2013,19(3):175-178. |
| MRI和PET-CT对放疗后鼻咽癌颅底复发的诊断价值 |
| Diagnostic Value of Magnetic Resonance Imaging(MRI) and Positron Emission Tomography(PET) in Nasopharyngeal Carcinoma (NPC) Post-radiation with Skull Base Recurrence |
| 投稿时间：2012-10-19 |
| DOI：10.11735/j.issn.1671-170X.2013.03.B2012532 |
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| 中文关键词: 放射疗法 鼻咽肿瘤 磁共振成像 体层摄影术，发射型计算机 颅底 复发 |
| 英文关键词:radiotherapy nasopharyngeal neoplasms magnetic resonance imaging tomography,emission computed skull base recurrence |
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| 摘要点击次数: 1955 |
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| 中文摘要: |
| 摘 要: ［目的］ 比较磁共振成像（MRI）和18F-氟代脱氧葡萄糖—正电子发射计算机体层摄影（PET-CT）对放疗后鼻咽癌颅底复发的诊断价值。 ［方法］ 48例放疗后的鼻咽癌患者，均行鼻咽MRI和PET-CT显像。比较MRI和PET-CT诊断放疗后鼻咽癌颅底复发的灵敏度、特异性、准确率、阳性预测值及阴性预测值。［结果］ PET-CT和MRI对颅底复发诊断的灵敏度、特异性、准确率、阳性预测值和阴性预测值分别为94.1%和88.2%、42.9%和35.7%、79.2%和72.9%、80.0%和76.9%、75.0%和55.6%。PET-CT和MRI联合时灵敏度、特异性、阳性预测值、阴性预测值和准确率分别为93.8%、31.3% 、73.2%、71.4%和72.9%，与MRI和PET-CT比较，差异均无统计学意义（P>0.05）。颅底有软组织者复发组占85.3%，未复发组仅占28.6%，差异有统计学意义（P<0.05）。复发组标准化摄取值（SUV）平均为7.59（1.9~15.4），未复发组SUV为3.86（0.7~8.4），差异有统计学意义（P=0.000）。 ［结论］ PET-CT和MRI在鼻咽癌放疗后疑似颅底复发诊断上无明显差异，两者联合亦未显示优势。 |
| 英文摘要: |
| Abstract:［Purpose］ To compare the value of positron emission tomography(PET) using 18-fluoro-2-deoxyglucose(FDG) with magnetic resonance imaging(MRI) in nasopharyngeal carcinoma(NPC) post-radiation with skull base recurrence. ［Methods］ The imaging of MRI and PET-CT scans of 48 post-radiation NPC patients were reviewed. The sensitivity，specificity，accuracy，positive predictive value(PPV) and negative predictive value(NPV) of MRI and PET-CT were calculated and analyzed. ［Results］ For detecting skull base recurrence of post-radiation NPC，the sensitivity of PET-CT and MRI were 94.1% and 88.2%，respectively；specificity，42.9% and 35.7%； accuracy，79.2% and 72.9%； PPV，80.0% and 76.9%；NPV，75.0% and 55.6%，respectively. When combined detection of PET-CT and MRI，the sensitivity，specificity，PPV，NPV and accuracy were 93.8%，31.3%，73.2%，71.4% and 72.9%，respectively，without significant difference compared with PET-CT or MRI alone(P>0.05). Soft-tissue mass was found in 85.3%（29 of 34）of recurrent patients，and in 28.6%(4 of 14)of non-recurrent patients，with significant difference between them(P<0.05). The average standard uptaken value(SUV) was 7.59(range 1.9～15.4) in the recurrent group，while 3.86（range 0.7～8.4）in the non-recurrent group，with significant difference(P=0.000). ［Conclusion］ In patients suspicious of recurrence in the skull base after radiotherapy in NPC，there is no significant difference in the diagnostic value between PET-CT and MRI，neither is combined detection of PET-CT and MRI. |
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