| 周 莹,朱莹杰.大肠癌疗效及预后相关基因研究进展[J].肿瘤学杂志,2013,19(4):302-306. |
| 大肠癌疗效及预后相关基因研究进展 |
| Research Progress in Treatment Efficacy and Prognosis Related Genes of Colorectal Cancer |
| 投稿时间：2012-10-19 |
| DOI：10.11735/j.issn.1671-170X.2013.04.B2012531 |
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| 中文关键词: 结直肠肿瘤 分子生物学 疗效 预后 基因 肿瘤标志物 |
| 英文关键词:colorectal neoplasms molecular biology efficacy prognosis genes tumor markers |
| 基金项目: |
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| 摘要点击次数: 1615 |
| 全文下载次数: 958 |
| 中文摘要: |
| 摘 要:药物疗效及肿瘤的复发转移是影响大肠癌患者预后的主要因素。随着肿瘤分子生物学领域的研究进展，出现了一些新的相关标志物，其中研究较多的基因肿瘤标志物，如ras基因、BRAF基因、C-erbB-2基因、MMR基因、PIK3CA、PI3K、PTEN等。这些基因的突变及功能异常均可影响大肠癌的发生、发展、药物疗效及预后，成为目前研究的热点，该文就这些基因标志物与大肠癌疗效及预后的关系作一综述。 |
| 英文摘要: |
| Abstract: Medicine efficacy and cancer recurrence or metastasis are the main factors which influence the prognosis of patients with colorectal cancer. With the research progress in oncologic molecular biology，some related new markers appear. Among these markers，gene related tumor markers are more interested in research，such as ras，BRAF，C-erbB-2，MMR，PIK3CA，PI3K，PTEN，etc. The mutation and dysfunction of these genes can influence the occurrence，development，treatment efficacy and prognosis in colorectal cancer. So they are becoming the hot spots of research now. In this paper，the relationship of these gene related tumor markers with treatment efficacy and prognosis of colorectal cancer were discussed. |
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